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The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery
Medicinal Research Reviews, 08/31/09
Rollinger JM et al. – The increasing structural insight and molecular understanding of viral proteins on the one hand and the advent of innovative computer–assisted technologies on the other hand have facilitated a ationalized access for the discovery of small chemical entities with antirhinoviral (anti–HRV) activity. This review will summarize existing structural knowledge about HRV, focus on mechanisms of anti–HRV agents from synthetic and natural origin, and demonstrate strategies for efficient lead structure discovery.
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