Urology Medical News about testosterone recovery;hormonal therapy;prostate cancer;risk of death

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Interval to testosterone recovery after hormonal therapy for prostate cancer and risk of death
International Journal of Radiation Oncology*Biology*Physics, 09/01/09

D'Amico AV et al. – A longer TTR after RT plus 6 months of HT for unfavorable-risk PCa is associated with a lower risk of death in men with no or minimal comorbidity.

Methods

206 men with localized, unfavorable risk PCa were randomized to RT or RT + 6 mos HT

Results

Of the 102 men randomized to receive RT and HT, 57 (56%) had a TTR of >2 years, and none of these men had died of PCa after a median follow-up of 7.6 years.
As the TTR increased, the risk of death decreased significantly.
The survival estimates were similar across the TTR values in men with moderate to severe comorbidity; however, these estimates increased significantly with decreasing PCa-specific mortality as the TTR increased in men with no or minimal comorbidity.

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