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Swoboda A et al. – Especially in the setting of total prostate–specific antigen (PSA) in the intermediate range of 4–10 ng/ml and a negative digital rectal examination, the use of the free/total (F/T) PSA ratio has proved to be an effective tool in prostate cancer screening. To prevent loss of quality in a setting with delayed F/T PSA measurement, the authors recommend that physicians compare their own data critically with presented results and eventually adapt the cutoffs individually.

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