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See Latest ArticlesEnvironmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract
BJU International, 08/19/09
Colin P et al. – As some genetic polymorphisms are associated with an increased risk of cancer or faster disease progression, there is variability in interindividual susceptibility to the development of UUT carcinoma when exposed to the aforementioned risk factors Cytosolic sulfotransferases (SULTs) catalyse the detoxification of many environmental chemicals but also in the bioactivation of dietary and other mutagens. Polymorphism of the SULT gene, is thought to confer susceptibility to upper tract tumours.
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