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See Latest ArticlesAssessing the Effects of Transforming Growth Factor-beta1 on Bladder Smooth Muscle Cell Phenotype. I. Modulation of In Vitro Contractility
The Journal of Urology, 08/24/09
Parekh A et al. – Increased transforming growth factor–beta1 expression in the detrusor of spinal cord injured rats implies up–regulation and localized signaling in response to injury. Bladder smooth muscle cells showed a loss of contractility in response to transforming growth factor–beta1 in all cell populations. A shift in phenotype was confirmed by high molecular weight caldesmon immunostaining. These results suggest that transforming growth factor–beta1 can modulate bladder smooth muscle cell function and may be a crucial regulator of bladder smooth muscle cell phenotype in pathological bladder conditions.
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