Urology Medical News about Manganese superoxide dismutase, prostate cancer

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Association between manganese superoxide dismutase gene polymorphism and risk of prostate cancer: a meta-analysis
Urology, 08/14/09

Liwei L et al. – In a trial to examine the association between 2 mitochondrial manganese superoxide dismutase (MnSOD) genetic polymorphisms (Ala-9Val and Ala-16Val) and prostate cancer (PCa) susceptibility,it appears that no significant association was found between the Ala-9Val and Ala-16Val polymorphisms in MnSOD and PCa susceptibility.

Methods

A comprehensive search was conducted to identify all case-control studies of MnSOD polymorphisms and PCa risk.
Statistical analysis was performed with the software program Stata, version 8.0, and Review Manage, version 4.2.

Results

9 eligible studies, including 3268 cases and 5907 controls, relating the MnSOD polymorphism to the risk of PCa were identified.
For the Ala-9Val polymorphism, 5 studies, including 889 cases and 1841 controls, found no significant associations between MnSOD polymorphism and risk of developing PCa in the recessive, dominant, and co-dominant models.
In sensitivity analysis, exclusion of the study with the controls not in Hardy-Weinberg equilibrium, no significant associations were found in the recessive, dominant, and co-dominant models.
For the Ala-16Val polymorphism, 4 studies, including 2379 cases and 4066 controls, found no significant association between MnSOD polymorphism and risk of developing PCa in both co-dominant, recessive, and dominant models.

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