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See Latest ArticlesFree Radical Theory of Aging: Implications in Male Infertility
Urology, 07/31/09
Desai N et al. – This review examines the effect of mitochondrial generation of reactive oxygen species (ROS) and aging on human spermatozoa and seminal antioxidants. The authors discuss the effect of continuous ROS production on biomarkers of aging, such as germ cell telomeres and telomerase, lipofuscin, and amyloid. These markers may be responsible for telomere shortening and subsequent decrease in sperm count, decline in testosterone concentration, and decline in motility with aging. Excessive ROS can also damage mitochondrial deoxyribonucleic acid and sperm nuclear DNA, contributing to paternally transmitted diseases. ROS generation has a central role in the pathophysiology of age–related decrease in male fertility.
Ashok Agarwal, 08/11/09
| Recent studies suggested male fertility may decline with aging. In the present review, we linked the decline in male fertility due to aging with the free radical theory of aging. We discuss the continuous mitochondrial generation of ROS (reactive oxygen species), decline in the activities of antioxidant enzymes and accumulation of lipofuscin and amyloid in male reproductive system with aging. All of these can lead to decline in sperm count, decline in motility, and testosterone level as well as sperm nuclear damage. Thus, we conclude that ROS play central role in pathophysiology of decreased fertility with aging. |
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