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Toque HA et al. – Sildenafil, vardenafil, and tadalafil relax HCC tissues in a concentration–dependent manner, but the maximal relaxation obtained with tadalafil was significantly lower than that obtained with sildenafil and vardenafil. Moreover, the PDE–5 inhibitors interacted with endogenous and exogenous NO, amplifying its HCC relaxation.

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