Urology Medical News about androgen deprivation therapy, prostate cancer

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Physical activity for men receiving androgen deprivation therapy for prostate cancer: benefits from a 16-week intervention
Supportive Care in Cancer, 07/29/09

Culos-Reed SN et al. - In a study to investigate the effects of physical activity (PA) intervention for men receiving androgen deprivation therapy (ADT) on PA behavior, quality of life, and fitness measures, it was reported that PA effectively attenuates many side effects of ADT and should be recommended to prostate survivors as an alternate therapy. Determining maintenance of this behavior change will be important for understanding how the long-term benefits of increased activity levels may alleviate the late effects of ADT.

Methods

100 participants were randomized into an intervention (n?=?53) or a wait-list control group (n?=?47), with 11 dropping out of the intervention group and 23 dropping out of the wait-list control group prior to post-testing.
The intervention consisted of both an individually tailored home-based aerobic and light resistant training program and weekly group sessions.
PA, quality of life, fitness, and physiological outcomes were assessed before and after the 16-wk intervention.

Results

Significant increases in PA, supported by changes in girth measures and blood pressure, support the beneficial impact of the intervention.
Positive trends were also evident for depression and fatigue.
Due to the high dropout rate, these results must be interpreted with caution.

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