Urology Medical News about renal cell carcinoma, pediatrics

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Pediatric renal cell carcinoma
Journal of Pediatric Urology , 07/23/09

Sausville JE et al. - In a review of pediatric renal cell carcinoma (RCC), it would appear that there are no adequately powered studies to support conclusions about adjuvant or neoadjuvant chemotherapy for children with RCC. This may be ameliorated by a multi-institutional protocol that is enrolling pts.

Methods

RCC comprises about 5% of pediatric renal neoplasms.
It has been recognized as a second malignancy in multiple reports.
It is generally symptomatic at diagnosis, and most children with RCC present with more locally advanced disease than do adults.

Results

Contemporary investigation of pediatric RCC has demonstrated that a large percentage of these tumors bear cytogenetic translocations involving the MiT family of transcription factors.
Surgical therapy for children resembles operative intervention for adult RCC, though debate continues about the precise role of lymph node dissection.

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