Urology Medical News about Pelvic nodal involvement, 18F-FDG-PET/CT, inguinal node-positive penile carcinoma

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. 2008 Exclusive Survey—Earnings: Good news for primary care income

3. Medicare pay-for-reporting effort draws fire from frustrated doctors

4. Debunking Myths in the US Healthcare System

5. Doctors and the DEA Free full text

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Scanning with 18F-FDG-PET/CT for detection of pelvic nodal involvement in inguinal node-positive penile carcinoma
European Urology, 07/21/09

Graafland NM et al. - In a trial to evaluate the diagnostic accuracy of fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) with computed tomography (CT; 18F-FDG PET/CT) scanning in determining further metastatic spread in pts with tumour-positive inguinal nodes, it appears that penile carcinoma pts with inguinal lymph node involvement have an increased risk for further lymphatic spread. PET with CT scanning appears promising for detecting pelvic metastases with great accuracy in these pts, and it identifies distant metastases.

Methods

18 pts with penile squamous cell carcinoma with unilateral or bilateral cytologically tumour-positive inguinal disease underwent whole-body 18F-FDG-PET/CT scanning for tumour staging.
Images were blindly assessed by 2 nuclear medicine physicians.
All scans were evaluated for pelvic nodal involvement per basin and for distant metastases.
Histopathology (when available), radiologic imaging, and clinical follow-up (with a minimum of 1 yr) served as a reference standard.
Diagnostic value of PET/CT scanning for predicting pelvic nodal involvement was evaluated using standard statistical methods.

Results

The reference was available in 28 of the 36 pelvic basins.
Of the 11 tumour-positive pelvic basins, 10 were correctly predicted by PET/CT scan, as were all 17 tumour-negative pelvic basins.
PET/CT scan showed a sensitivity of 91%, a specificity of 100%, a diagnostic accuracy of 96%, a positive predictive value of 100%, and a negative predictive value of 94% in detecting pelvic nodal involvement.
PET/CT scans showed distant metastases in 5 pts.
In 4 pts, presence of distant metastases could be confirmed, while in 1 pt, no radiologic confirmation was found for that particular lesion.

<< Previous
Sirolimus in Kidney Transplantation Indications and Practical...

Next >>
Posterior Urethral Valves: Primary Voiding Pressures and Kidney...