Urology Medical News about chemokine, prostate cancer, tissue expression

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. 2008 Exclusive Survey—Earnings: Good news for primary care income

3. Medicare pay-for-reporting effort draws fire from frustrated doctors

4. Debunking Myths in the US Healthcare System

5. Doctors and the DEA Free full text

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines
International Journal of Cancer, 07/29/09

Singh S et al. - In a study to we show whether primary prostate cancer (PCa) tissues and cell lines (LNCaP and PC3) express CXCR5, a specific chemokine receptor for CXCL13, it was concluded that these data demonstrate the clinical and biological relevance of the CXCL13-CXCR5 pathway and its role in PCa cell invasion and migration.

Methods

Chemokines and chemokine receptors have been shown to be involved in metastatic process of PCa.
It was tested whether primary PCa tissues and cell lines (LNCaP and PC3) express CXCR5, a specific chemokine receptor for CXCL13.

Results

Expression of CXCR5 was significantly higher in PCa cases vs normal match (NM) tissues.
CXCR5 intensity correlated (R2 = 0.97) with Gleason score.
While prostate tumor tissues with Gleason scores ≥7, displayed predominantly nuclear CXCR5 expression patterns, PCa specimens with Gleason scores ≤6 showed predominantly membrane and cytoplasmic expression patterns that were comparable to benign prostatic hyperplasia (BPH).
Similar to tissue expression, PCa cell lines expressed significantly more CXCR5 than normal prostatic epithelial cells (PrECs), and CXCR5 expression was distributed among intracellular and extracellular compartments.
Functional in vitro assays showed higher migratory and invasive potentials toward CXCL13, an effect that was mediated by CXCR5.
In both PCa cell lines, CXCL13 treatment increased expression of collagenase-1 or matrix metalloproteinase-1 (MMP-1), collagenase-3 (MMP-13), stromelysin-1 (MMP-3), stromelysin-2 (MMP-10) and stromelysin-3 (MMP-11).

<< Previous
Dual targeting of Bcl-2 and VEGF: A potential strategy to improve...

Next >>
Paraneoplastic syndromes in patients with urological malignancies

Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions
Oncogene, 11/19/09 Relevance Score: 89%

Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer
Cancer Immunology, Immunotherapy, 10/26/09 Relevance Score: 89%

The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts
Oncogene, 10/01/09 Relevance Score: 87%

Correlation of GREB1 mRNA with protein expression in breast cancer: validation of a novel GREB1 monoclonal antibody
Breast Cancer Research and Treatment, 11/04/09 Relevance Score: 84%

Periprostatic Adipose Tissue as a Modulator of Prostate Cancer Aggressiveness
The Journal of Urology, 10/01/09 Relevance Score: 82%