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See Latest ArticlesTumoral prostate shows different expression pattern of somatostatin receptor 2 (SSTR2) and phosphotyrosine phosphatase SHP-1 (PTPN6) according to tumor progression
Advances in Urology, 07/09/09
Cariaga-Martinez AE et al. - Somatostatin receptor 2 (SSTR2) and SHP-1 tyrosine phosphatase are 2 fundamental components on antiproliferative effect of somatostatin. Normal epithelial prostate cells express SHP-1 and SSTR2, but their expression levels are diminished or lost in advanced prostate cancer with an inverse ratio between protein expression and Gleason grade of tumor.
Methods- An evaluation of the expression of SSTR2 and SHP-1 (PTPN6) in normal prostate and their variation through tumoral progression in human prostate cancer
- Human prostate tissues were obtained from transrectal needle biopsies, transurethral resection, and retropubic or radical prostatectomy
- Specimens were graded according to the original report Gleason grading
- IHC was performed with different antibodies
- Epithelial expressions of both proteins, SHP-1 and SSTR2, in normal and benign hyperplasia are localized in the luminal side of duct and acinar cells
- Also, SSTR2 was expressed in stromal cells
- In malignant prostate tissue, SHP-1 was diminished in 28/45 cases or absent in 12/45 cases
- SSTR2 epithelial was diminished in 38/45 cases or lost in only 2/45 cases
- The intensity of immunostained was highly negative correlated with Gleason grade for 2 proteins
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