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Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors
Virchows Archiv, 07/06/09

Szabo PM et al. – Data suggest that adrenocortical tumorigenesis might be characterized by reduced histamine biosynthesis; furthermore, different adrenocortical tumor subtypes may show unique histamine receptor expression profiles.

Methods

An investigation of the involvement of histamine in human adrenocortical tumorigenesis
Expression of genes and proteins involved in:
- Biosynthesis (histidine decarboxylase, HDC)
- Action (histamine receptors: HRH1–HRH4), and
- Metabolism
  of histamine was examined in the normal human adrenal cortex and in adrenocortical tumors
15 normal adrenals and 43 tumors were studied
mRNA expression was examined by RT-PCR
Western-blotting and IHC were used for the study of proteins
Tissue histamine content was determined by ELISA

Results

All proteins involved in histamine biosynthesis and action were present both in the normal adrenal cortex and in the tumors studied
HDC expression and histamine content was highest in the normal tissues and lower in benign tumors
Whereas it was significantly less in adrenocortical cancer (ACCs)
HRH3 expression was higher in ACC samples than in the other groups

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