Urology Medical News about expression of Twist

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. 2008 Exclusive Survey—Earnings: Good news for primary care income

3. Medicare pay-for-reporting effort draws fire from frustrated doctors

4. Debunking Myths in the US Healthcare System

5. Doctors and the DEA Free full text

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

The expression of Twist has an impact on survival in human bladder cancer and is influenced by the smoking status
Urologic Oncology: Seminars and Original Investigations, 07/01/09

Fondrevelle ME et al. - In a trial to investigate the expression of Twist and those of E- and N-cadherin in human primary bladder tumor and to evaluate its prognostic value, it was found that positive Twist expression may be a useful prognostic marker for pts with bladder cancer. Its expression seems to be correlated to tobacco status of the pts.

Methods

To delineate the oncogenic role for Twist in human bladder cancer, E- and N-cadherin as well as Twist expression (n = 70) were evaluated by immunohistochemistry.
The prognostic value of these expressions were evaluated.
Researchers tried to correlate these protein expressions to the smoking status of the pts.
Overall survival (OS) and progression-free survival (PFS) were evaluated using the Kaplan-Meier method, and multivariate analysis was performed using the Cox proportional hazard analysis.

Results

Of the 70 bladder tumors, 28 (40%) cases were positive for Twist expression, 16 (23%) cases were negative for E-cadherin expression, and 12 (17%) were positive for N-cadherin expression.
When categorized into negative vs positive expression, Twist was associated with stage, grade, progression, and E-cadherin expression.
Positive Twist expression clearly predicted poorer PFS.
In multivariate analysis, both positive Twist expression and loss of E-cadherin expression were independent prognostic factors for PFS and only loss of E-cadherin expression for the OS.
Almost 60% (16/28) of pts with Twist-positive expression were current smokers at the time of the diagnosis, corroborating the fact that smoking modulates expression of epithelial mesenchymal transition markers including Twist.

<< Previous
Complications of Transperitoneal Laparoscopic Nephrectomy: A...

Next >>
Beyond PSA: Utility of novel tumor markers in the setting of...