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Clinical implications of hypoxia inducible factor in renal cell carcinoma
Urologic Oncology: Seminars and Original Investigations, 06/29/09

Smaldone MC et al. - In a review of the clinical implications of hypoxia inducible factor (HIF) in renal cell carcinoma (RCC), this report provides a directed review of recent discoveries defining the role of HIF in renal tumorigenesis and their relevance to clinical advances in targeted therapy for advanced RCC.

Methods

Management of RCC has made considerable strides in the past decade, due in large part to identification of the von Hippel Lindau (VHL) tumor suppressor as a negative regulator of HIF-α protein expression.

Results

Stabilization of HIF-α appears to be critical for renal tumorigenesis, and is observed even in VHL-independent RCC.
An understanding of the pathways that regulate expression and activation of the different HIF-α isoforms is key to delineating the mechanism of renal transformation and for development of novel therapeutics.
A number of agents targeting HIF-α or its transcriptionally-regulated genes have shown promise in treatment of RCC.
More effective treatment strategies are still needed.

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The anti-malaria agent artesunate inhibits expression of vascular endothelial growth factor and hypoxia-inducible factor-1 alpha in human rheumatoid arthritis fibroblast-like synoviocyte
Rheumatology International, 10/30/09 Relevance Score: 83%

Neuroprotective effect of combined hypoxia-induced VEGF and bone marrow-derived mesenchymal stem cell treatment
Child's Nervous System, 11/20/09 Relevance Score: 80%

Involvement of hypoxia-inducible factor-1 HiF(1[alpha]) in IgE-mediated primary human basophil responses
European Journal of Immunology, 11/18/09 Relevance Score: 80%

Hypoxia inducible factor-1alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes
Liver International, 10/08/09 Relevance Score: 80%

c-Jun Protects Hypoxia-Inducible Factor-1 from Degradation via Its Oxygen-Dependent Degradation Domain in a Nontranscriptional Manner
Cancer Research, 10/05/09 Relevance Score: 79%