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Isolated Familial Hypogonadotropic Hypogonadism and a GNRH1 Mutation
New England Journal of Medicine, 06/25/09

Bouligand J et al. - The authors identified a homozygous GNRH1 frameshift mutation, an insertion of an adenine at nucleotide position 18 (c.18-19insA), in the sequence encoding the N-terminal region of the signal peptide–containing protein precursor of gonadotropin-releasing hormone (prepro-GnRH) in a teenage brother and sister, who had normosmic IHH. This mutation results in an aberrant peptide lacking the conserved GnRH decapeptide sequence, as shown by the absence of immunoreactive GnRH when expressed in vitro. This isolated autosomal recessive GnRH deficiency, reversed by pulsatile GnRH administration, shows the pivotal role of GnRH in human reproduction.

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Hypogonadism Risk in Men Treated for Childhood Cancer
Internet Source, 11/05/09 Relevance Score: 90%

Hypogonadism Risk in Men Treated for Childhood Cancer
Journal of Clinical Endocrinology and Metabolism, 10/12/09 Relevance Score: 88%

Hypogonadism in men with erectile dysfunction may be related to a host of chronic illnesses
International Journal of Impotence Research, 10/02/09 Relevance Score: 83%

Outcome of gonadotropin therapy for male infertility due to hypogonadotrophic hypogonadism
Pituitary, 10/29/09 Relevance Score: 82%

Impaired Fibroblast Growth Factor Receptor 1 Signaling as a Cause of Normosmic Idiopathic Hypogonadotropic Hypogonadism
Journal of Clinical Endocrinology and Metabolism, 10/15/09 Relevance Score: 82%