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Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells
The Prostate, 06/19/09
Gibbs TC et al. - Although both LPA and S1P induce signal transduction in all prostate cancer cell lines studied, a proliferation response is observed only when the Erk, Akt, and FAK pathways are activated. Other responses to the lipid mediators, such as PLD activation, likely contribute to other cellular outcomes.
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