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Cariaga-Martinez AE et al. - Somatostatin receptor 2 (SSTR2) and SHP-1 tyrosine phosphatase are two fundamental components on antiproliferative effect of somatostatin. Normal epithelial prostate cells express SHP-1 and SSTR2, but we report that the levels of expression were diminished or lost for two proteins in advanced prostate cancer with an inverse ratio between protein expression and Gleason grade of tumor.

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