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Armstrong N. et al. - Diathermy vaporization followed by TURP also more effectively relieved symptoms and was less costly than other strategies, including initial TURP (repeated once if necessary). The implications of this study extend beyond men with BPH and health-care providers to clinical trial design. The model showed that sequences of treatments were more beneficial than one-off interventions. Restricting prospective controlled trials to comparison of single treatments could lead to potentially useful modalities being discarded, when in fact they might be beneficial if incorporated into a more clinically relevant multi-treatment regimen.

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