Urology Medical News about testicular cancer;sub-acute changes in cardiac function;cisplatin-based chemotherapy

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Evaluation of sub-acute changes in cardiac function after cisplatin-based combination chemotherapy for testicular cancer
British Journal of Cancer, 05/21/09

Altena R et al. - In a study to explore early sub-clinical changes in cardiac function in chemotherapy-treated testicular cancer survivors, it appears that at a median of 10 mos after cisplatin-based treatment for testicular cancer, tissue velocity imaging (TVI) decreased significantly, indicating a deterioration of diastolic cardiac function. Serum levels of N-Terminal pro-Brain Natriuretic Peptide (NT-proBNP) increased. The prognostic significance of these changes for future cardiovascular morbidity is not clear.

Methods

Cardiac function in testicular cancer patients was prospectively evaluated by echocardiography.
Systolic (Wall Motion Score Index) and diastolic (E/A-ratio and TVI) parameters, and serum levels of NT-proBNP were assessed before the start of chemotherapy and 1 yr later.
Echocardiography data were compared with an age-matched group of healthy controls.

Results

42 pts treated with bleomycin, etoposide, and cisplatin were evaluated (median age 27 yrs).
Systolic function and E/A-ratio did not change, whereas median TVI decreased (12.0 vs 10.0 cms-1).
Median levels of NT-proBNP increased (5 vs 18 pmoll-1).
Compared with controls, TVI before the start of chemotherapy was not significantly different.

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