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High-resolution DNA copy number and gene expression analyses distinquish chromophobe renal cell carcinomas and renal oncocytomas
BMC Cancer, 05/19/09
Yusenko MV et al. - The SNP-array analysis failed to detect recurrent small deletions, which may mark loci of genes involved in the tumor development. However, The authors have identified loss of chromosome 2, 10, 13, 17 and 21 as discriminating alteration between chromophobe RCCs and ROs. Therefore, detection of these chromosomal changes can be used for the accurate diagnosis in routine histology.
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