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See Latest ArticlesAssociation of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China
Cancer Epidemiology, 05/12/09
Song DK et al. - In a study to explore the association of polymorphisms in N-acetyltransferase 2 (NAT2), glutathione S-transferase (GST), cytochrome P450 (CYP) 2A6, and CYP 2A13 genes with susceptibility and clinicopathologic characteristics of bladder cancer in a Chinese population, It was suggested that NAT2 slow-acetylator, GSTM1 null, GSTM1/GSTT1-double null, and variant CYP2A6 genotypes may play important roles in the development of bladder cancer.
Methods- In a hospital-based case-control study of 208 cases and 212 controls matched on age and gender, genotypes were determined by PCR-based methods.
- Risks were evaluated by unconditional logistic regression analysis.
- Significant associations of the NAT2 slow-acetylator genotype, GSTM1 null genotype, and GSTM1/GSTT1-double null genotype correlate with increased risk of bladder cancer.
- Carriers with at least 1 CYP2A6*4 allele showed lower risk than non-carriers.
- Adjusted ORs for smokers with NAT2 slow-acetylator, GSTM1 null, GSTM1/GSTT1-double null genotype, and variant CYP2A6 genotypes were 2.99, 1.98, 2.66, and 0.41, respectively.
- NAT2 slow-acetylator, GSTM1 null, and GSTM1/GSTT1-double null genotypes were associated with higher tumor grade, and only NAT2 slow-acetylator genotype was associated with higher tumor stage.
- CYP2A13 was not associated with risk or tumor characteristics.
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