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Masked volume wise principal component analysis of small adrenocortical tumours in dynamic [11C]-metomidate positron emission tomography
BMC Medical Imaging , 04/23/09

Razifar P et al. – The results indicate that the definition of regions of interest (ROIs) may be more accurate and precise in Masked Volume Wise Principal Component 1 (MVW-PC1) images than in conventional summed images. This might improve the precision of PET measurements, for instance in therapy monitoring as well as for delineation of the tumour in radiation therapy planning.

Methods

Study applies MVW-PCA to 14 dynamic 11C-metomidate-PET (MTO-PET) examinations of 7 pts with small adrenocortical tumours
MTO-PET was performed before and 3 days after starting per oral cortisone treatment
The whole dataset, reconstructed by filtered back projection (FBP) 0-45 minutes after the tracer injection, was used to study the tracer pharmacokinetics

Results

Early, intermediate and late pharmacokinetic phases could be isolated in this manner
The MVW-PC1 images correlated well to the conventionally summed image data but the image noise in the former was considerably lower
PET measurements performed by defining ROIs comprising 4 contiguous pixels with the highest radioactivity concn showed a trend towards higher SUVs when the ROIs were outlined in the MVW-PC1 component than in the summed images
Time activity curves derived from "50% cut-off" ROIs based on an isocontour function showed a decrease of the SUVs in normal adrenal glands and in adrenocortical adenomas after cortisone treatment

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