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See Latest ArticlesIncreased risk of testicular germ cell cancer among infertile men
Archives of Internal Medicine, 03/02/09
Walsh TJ et al. - In a trial to explore the association between male infertility and subsequent development of testicular cancer in a US-based cohort, it was found that men with male factor infertility have an increased risk of developing testicular cancer, suggesting the existence of common etiologic factors for infertility and testicular cancer.
Methods- 51,461 couples evaluated for infertility from 1967 to 1998 were recruited from 15 California infertility centers.
- Data on 22,562 identified male partners were linked to the California Cancer Registry.
- Incidence of testicular cancer was compared with incidence in an age-matched sample of men from the general population using the SEER program.
- Risk for testicular cancer was analyzed in men with and without male factor infertility using a Cox proportional hazards regression model.
- 34 postinfertility-diagnosis cases of histologically confirmed testicular cancer were identified.
- Men seeking infertility treatment had an increased risk of subsequently developing testicular cancer, with a markedly higher risk among those with known male factor infertility.
- In multivariable analysis, men with male factor infertility were nearly 3 times more likely to develop testicular cancer vs those without.
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