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See Latest ArticlesRole of maximum androgen blockade in advanced prostate cancer
Indian Journal of Urology, 02/19/09
Ayyathurai R et al. - In a review of the role of maximum androgen blockade (MAB) in advanced prostate cancer (PC), it seems that the standard first line treatment should be a monotherapy, consisting of orchiectomy or LHRH agonist. MAB still has a role as a short-term therapy (2-4 wks). The ongoing large sample population based prospective studies may add new dimensions in use of MAB in treatment of PC in the future.
Methods- Androgen ablation is the mainstay treatment for advanced PC.
- Researchers proposed that MAB therapy with antiandrogen agent in combination with castration might result in a better outcome among pts with advanced PC.
- In the last 2 decades, numerous trials and pooled data analyses were conducted to optimize the role of MAB in treatment of metastatic PC.
- Non-steroidal antiandrogens administered as part of MAB proved to have a small (3%) survival benefit, however, the magnitude of this benefit is of questionable clinical significance.
- Available evidence suggests that MAB should not be routinely offered to pts with metastatic PC, but it should remain an option when discussing management.
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