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Testosterone administration to men with testosterone deficiency syndrome after external beam radiotherapy for localized prostate cancer: preliminary observations
BJU International, 02/02/09

Morales A et al. - In a study to assess the effects of testosterone supplementation in men with testosterone deficiency syndrome (TDS) after external beam radiotherapy (EBRT) for localized prostate cancer, it seems that men with TDS after EBRT for localised prostate cancer are candidates for testosterone therapy. There is a need for more information about safety and efficacy of testosterone therapy in men successfully treated for localized prostate cancer, because there is evidence indicating hypogonadism in these pts, compromising their quality of life and longevity, independent of the cancer.

Methods

5 men with significant signs of TDS after treatment for localized prostate cancer with EBRT were treated with testosterone once their prostate-specific antigen (PSA) level had reached the nadir.

Results

Mean level of testosterone before supplementation was 5.2 nmol/L and duration of follow-up while on supplementation was 14.5 mos.
At the last visit, testosterone levels were 17.6 nmol/L.
1 of 5 pts had a transitory increase in PSA level but none had levels of >1.5 ng/mL.
All pts reported a marked response in the manifestations of TDS, ie, 4 each reported decreased hot flushes, decreased fatigue, and improved libido, and 2 reported improved erectile function.

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Validation in a Multiple Urology Practice Cohort of the Prostate Cancer Prevention Trial Calculator for Predicting Prostate Cancer Detection
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A prospective study of lifetime physical activity and prostate cancer incidence and mortality
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Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men
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Prostate specific antigen for early detection of prostate cancer: longitudinal study
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