Urology

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Association between colorectal cancer and urologic cancers
Archives of Internal Medicine, 05/13/08

Calderwood AH et al. – Previous findings on renal pelvis/ureteral cancer and a follow up of the history of colorectal cancer (CRC) supports a possible common pathogenetic mechanism between CRC and urologic cancers and may have implications for screening guidelines.

• Study to quantify the risk for CRC after urologic cancer and the risk for urologic cancer after CRC in pts w/o known genetic syndromes
• A retrospective cohort analysis of the Surveillance, Epidemiology, and End Results from program database from 1973 to 2000 was performed
• Standard incidence ratios (SIRs) of observed to expected cases of invasive CRC were calculated for each urologic cancer site based on age, sex, ethnicity, and calendar year of diagnosis
• Similar analysis was performed to determine the SIRs of urologic cancers in pts with previous CRC

• Overall, the risk for CRC was increased among pts with previous ureteral cancer and renal pelvis cancer
• This risk was greatest among pts who received the diagnosis of renal pelvis or ureteral cancer before the age of 60 yrs
• There was a minimal increased risk for subsequent CRC in pts with bladder or renal parenchymal cancer
• Overall, the risk for urologic cancer was increased after a diagnosis of CRC
• Highest risk for subsequent renal pelvis and ureteral cancers was observed in pts with a CRC diagnosis before the ages of 50-60 yrs or multiple primary CRCs

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