Investigation of a new 1,3-diarylpropenone as a potential antimitotic agent targeting bladder carcinoma Martel-Frachet V et al. - After treating the cells with IPP51 for 24 h, the title compound induced a predominant and reversible G2+M accumulation at the prometaphase stage of mitosis. However, when used for a longer period, it leads to cell apoptosis. These results suggest that the compound has potential anticancer activities, which could be useful in bladder cancer treatment. [more...]
