Beyond PSA: Utility of novel tumor markers in the setting of elevated PSA
Lin DW - In a review of the utility of novel tumor markers in the setting of elevated prostate-specific antigen (PSA), this article will first highlight several characteristics of an ideal biomarker, then focus on select emerging biomarkers for detection of prostate cancer (PCa). Methods- Introduction of prostate-specific antigen (PSA) for PCa screening and detection has been used for over 20 yrs and has dramatically changed the face of PCa.
- Although it is a highly sensitive serum test, its routine use has been the subject of continued controversy owing to its limited specificity.
Results- Due to this lack of specificity, many have proposed modifications of PSA in an attempt to bolster the performance of this analyte.
- The human genome project and high throughput gene expression profiling has recently yielded several promising molecular biomarkers for PCa detection beyond PSA or PSA modifications.
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