Impact of age and gender on the clinicopathological characteristics of bladder cancer
Gupta P et al. - Data suggest that transitional cell carcinoma (TCC) is the predominant cancer, with significant male preponderance among Indian patients. Younger patients have low-grade disease; hematuria is the most common presentation. Greater awareness is needed not to overlook bladder cancer. Methods- Study to determine the impact of age and gender on the clinicopathological characteristics of histologically confirmed bladder cancer in India
- From Jan 2001-June 2008, records of pts (n=561) with bladder cancer were evaluated for:
- Age and gender at presentation
- Clinical symptoms
- Cystoscopic finding
- History of smoking, and
- Histopathological characteristics
Results- 97% of the pts presented with painless hematuria
- Mean age: 60.2 ± 4.4 yrs; male to female ratio: 8.6:1
- TCC was the most common histological variety, which was present in 97.71% of the pts
- 26% pts had muscle invasive disease at the time of presentation:
- However, 34.5% pts did not show any evidence of detrusor muscle
- In pts with nonmuscle-invasive bladder carcinoma, 55% had p Ta while 45% had p T1
- Overall, 44.7% pts had low-grade disease
- Among pts <60 yrs, low-grade and low-stage disease were more prevalent vs those >60 yrs
- Incidence of smoking was much higher among males vs females
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