Does early prostate-specific antigen doubling time (ePSADT) after radical prostatectomy, calculated using PSA values from the first detectable until the first recurrence value, correlate with standard PSADT? A report from the Shared Equal Access Regional Cancer Hospital Database Group
Teeter AE et al. – Although early PSA doubling time (ePSADT) and PSADT were significantly related, the overall correlation was poor. However, a long ePSADT correlated well with a long PSADT and is thus useful in identifying men at low risk for prostate cancer-specific mortality very early in their biochemical recurrence (BCR).Methods- Aim was to determine if ePSADT correlated with 'standard' PSADT following BCR
- Spearman's correlation was used to determine the correlation between ePSADT and PSADT among 157 men
- These men underwent RP between 1988 and 2005 and had a calculable ePSADT and PSADT
- ePSADT threshold was examined and their positive and negative predictive values (PPV and NPV, respectively), to predict aggressive recurrences (PSADT of <9 mo)
Results- ePSADT was significantly, though poorly, correlated with PSADT
- ePSADT more accurately predicted PSADT among men with a long ePSADT
- Of men with an ePSADT of ≥20 or ≥15 mo, the NPV for an aggressive recurrence was 98% and 93%, respectively
- However, among men with an ePSADT of <3 mo, the PPV for aggressive recurrence was only 39%
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