Interest of methylated genes as biomarkers in urothelial cell carcinomas of the urinary tract
Phe V et al. - There is evidence that the extent of the mutator and methylator phenotypes in UCCs differs with tumour location, perhaps suggesting that carcinogens affect the urinary tract in different ways. For all loci studied except DAPK, there was more frequent methylation in UUT-UCCs than in the bladder cancers; this difference was statistically significant for hMLH1, RARB, E-cadherin, p16 and MINT31. In contrast to UUT-UCCs, hMLH1 and MINT31 were rarely methylated in bladder tumours, suggesting that they play a role in UUT carcinogenesis but not bladder cancer. [more...]
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