Urinary Stone Formers with Hypocitraturia and ‘Normal’ Urinary pH Are at High Risk for Recurrence

Urologia Internationalis, 05/04/2012

Hypocitraturia with normal urine pH is an entity indicating a high risk for recurrence. Since there was no correlation between citrate and pH, urea and ammonia, respectively, citrate excretion is not regulated in these patients as usual. There may be a link to calcium excretion. Potentially, these patients have defects in the renal tubular citrate carriers which may be genetically determined. Genetic examinations should be performed to elucidate a potential genetic disorder in hypocitraturia–normal pH stone formers.

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