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Identification of lesions indicating rejection in kidney transplant biopsies: tubulitis is severely under-detected by conventional microscopy
Nephrology Dialysis Transplantation, 08/31/2011
Elshafie M et al. – The authors conclude that tubulitis is missed very frequently, but the Banff classification seems to be ‘calibrated’ to allow for this and it does not seriously affect the identification of clinically significant acute rejection. Immunostaining is therefore not indicated in routine practice because (by Banff criteria) it would result in over–diagnosis of rejection. Intimal arteritis can indicate acute rejection even if extremely mild.