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New Method for Differentiating Chronic Prostatitis/Chronic Pelvic Pain Syndrome IIIA From IIIB Involving Seminal Macrophages and Monocytes
Urology, 09/02/2011
Aghazarian A et al. – The quantification of seminal macrophages and monocytes is a simple, rapid, and reproducible technique by which to differentiate chronic prostatitis/chronic pelvic pain syndrome (CPPS) IIIA from IIIB.
Methods- Patients affected with chronic pelvic pain syndrome (CPPS) were classified as having the IIIA (n = 11) and IIIB (n = 30) subtypes according to the peroxidase positive leukocyte concentration in semen; 18 healthy individuals served as controls.
- Seminal inflammatory markers, including polymorphonuclear elastase, interleukin (IL)–6 and IL–8, and numbers of macrophages/monocytes (MMs) per 50 fields of 1000× magnification (high–power field [hpf]), were determined for all patients.
- The numbers of MMs/50 hpf correlated significantly with the peroxidase positive leukocyte counts and IL–8, IL–6, and polymorphonuclear elastase levels (all P < .001).
- Data from the analysis of receiver operating characteristic curves (area under the curve 0.912 ± 0.073; P < .001) showed a sensitivity of 90.9% and specificity of 86.7% at a cutoff value of 5 MMs/50 hpf.
- The positive and negative predictive value was 71.4% and 96.3%, respectively.
- The median concentrations of IL–6, IL–8, and elastase in the patients with CPPS with ≥5 MMs/50 hpf differed significantly (P ≤ .002) from those in the patients with <5 MMs/50 hpf.
