Antimuscarinics for the treatment of overactive bladder: understanding the role of muscarinic subtype selectivity

International Urogynecology Journal, 04/20/2011

Antimuscarinic agents differ widely in their propensity to cause cognitive and cardiovascular (CV) effects, which appear mainly to be related to differences in their relative selectivity for binding to non–M3 receptors, including M1 receptors in the brain and cardiac M2 receptors. Cognitive and CV effects are especially pertinent for the overactive bladder (OAB) patient who tends to be older with various comorbidities and is often taking multiple medications. Hence, it is important to consider the risk/benefit balance of antimuscarinic agents when selecting OAB treatment.

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