Effectiveness of intravenous lidocaine versus intravenous morphine for patients with renal colic in the emergency department BMC Urology, 05/09/2012

Soleimanpour H et al. – Changing the smooth muscle tone and reducing the transmission of afferent sensory pathways, lidocaine causes a significant reduction in pain.

• In a prospective randomized double-blind clinical trial performed in the emergency department of Imam Reza educational hospital of Tabriz, Iran, the authors studied 240 patients, 18- 65years old, who were referred due to renal colic.
• Patients were divided into two groups.
• In group I (120 people) single-dose intravenous lidocaine (1.5mg/kg) was administered and in group II (120 people) single-dose intravenous morphine (0.1mg/kg) was administered slowly.
• Visual Analogue Pain Scale (VAS) was recorded while admission, 5, 10, 15 and 30minutes after injection.
• Statistical data and results were studied using descriptive statistics as percentage and Mean +/- SD.
• To compare the response to treatment, Mann-Whitney U-test was used in two groups.
• Consequently, the data were analyzed using the SPSS16 software.

• Pain score measured in two groups five minutes after the injection of lidocaine and morphine were 65 % and 53 % respectively (95% CI 0.60-0.69, CI 0.48-0.57, p=0.0002).108 (90 %) patients (95 % CI 0.84 - 0.95) from group I and 84 (70%) patients (95 % CI 0.62-0.78) from group II responded appropriately at the end of the complete treatment.
• The difference was statistically significant (p=0.0001).