Urology - Clinical Pharmacology News & Articles

Now available on MDLinx Urology, find daily updates summarizing the top literature from over 2,000 peer-reviewed journals, including Journal of Urology, European Urology, The Prostate, and more. Find coverage of the kidney, bladder, penis/urethra and prostate. View article summaries by subspecialty and disease state, including peds urology, urologic oncology, stone disease, infections and STDs, urologic imaging, ureteral disease, voiding and incontinence, infertility, laparoscopy and other surgical techniques, and additional hot topics in your field. Find exclusive content only available on MDLinx Urology like articles highlighted by physician editor D. Scott Cunningham, MD, PhD, and clinical pearls gleaned from The Smartest Doc quiz competitions and Physician Reviews.

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Latest (2) Full Text Articles (71)

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1 Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism Cancer Research, May 20, 2013 Clinical Article

2 Efficacy of Sotrastaurin Plus Tacrolimus After De Novo Kidney Transplantation: Randomized, Phase II Trial Results American Journal of Transplantation, May 20, 2013 Clinical Article

Prior Articles

3 A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases Clinical Cancer Research, May 17, 2013 Clinical Article

4 Prescription Opioids for Back Pain and Use of Medications for Erectile Dysfunction Spine, May 17, 2013 Evidence Based Medicine Clinical Article

5 Cephalothin susceptibility testing as class representative for oral cephalosporins: is it time to move on Diagnostic Microbiology and Infectious Disease, May 17, 2013 Clinical Article

6 A phase 3, placebo controlled study of the safety and efficacy of avanafil for the treatment of erectile dysfunction after nerve sparing radical prostatectomy The Journal of Urology, May 16, 2013 Clinical Article

7 Evaluation of Mycophenolic Acid Exposure Using a Limited Sampling Strategy in Renal Transplant Recipients American Journal of Nephrology, May 15, 2013 Clinical Article

8 Basiliximab induction in renal transplantation: Long-term outcome Full Text Saudi Journal of Kidney Diseases and Transplantation, May 14, 2013 Clinical Article

9 Image-directed, tissue-preserving focal therapy of prostate cancer: a feasibility study of a novel deformable MR-US registration system BJU International, May 13, 2013 Clinical Article

10 Optimization of initial prostate biopsy in clinical practice: sampling, labeling and specimen processing The Journal of Urology, May 13, 2013 Review Article

11 Intraurethral tramadol alleviates rigid cystoscopy-related pain in men International Journal of Urological Nursing, May 13, 2013 Clinical Article

12 A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer Investigational New Drugs, May 7, 2013 Clinical Article

13 Platinum-Based Chemotherapy for Variant Castrate-Resistant Prostate Cancer Clinical Cancer Research, May 7, 2013 Clinical Article

14 New treatment options for castration-resistant prostate cancer American Journal of Health-System Pharmacy, May 6, 2013 Clinical Article

15 Botulinum toxin treatment for bladder dysfunction International Journal of Urology, May 6, 2013 Clinical Article

16 Botulinum toxin-what urologic uses does the data support? Current Urology Reports, May 3, 2013 Review Article

17 A phase II study of gemcitabine and oxaliplatin in advanced transitional cell carcinoma of the bladder Cancer Chemotherapy and Pharmacology, May 3, 2013 Clinical Article

18 Statin use in relation to prostate cancer outcomes in a population-based patient cohort study The Prostate, May 2, 2013 Clinical Article

19 A phase 3, double-blind, randomised, parallel-group, placebo-controlled study of oral weekly alendronate for the prevention of androgen deprivation bone loss in nonmetastatic prostate cancer: the cancer and osteoporosis research with alendronate and leuprolide (coral) study Full Text European Urology, May 2, 2013 Clinical Article

20 Clinical efficacy of collagenase clostridium histolyticum in the treatment of peyronie's disease by baseline penile curvature severity stratum: results from two large double-blind, randomized, placebo-controlled phase 3 studies Urology Times, May 1, 2013 Clinical Article

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Clinical Pearls in Urology

Because temozolomide is associated with changes in male fertility, consider referring patients for sperm banking prior to initiating chemotherapy for glioblastoma multiforme (GBM)
The schedule of radium-223 used in the ALSYMPCA trial is 5 minute infusion every 4 weeks x6 doses. Given in this fashion, it significantly improved median OS, time to SRE and time to PSA progression in men with advanced cancer of the prostate without demonstrable side effects
In RTOG 94-08 the addition of short course androgen deprivation to radiation therapy for men with intermediate risk cancer of the prostate resulted in a 50% reduction in disease specific mortality at 10-years

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Highlights in Urology

Red meat cooked at high temperatures increases risk of advanced cancer of the prostate

Researchers at the University of Southern California have reported a risk between advanced cancer of the prostate and red meats cooked at high temperature, pan-frying, and prepared "well done." The study involved 1140 men with advanced cancer of the prostate, 717 men with localized cancer of the prostate, and 1096 healthy controls from the California Collaborative Prostate Cancer Study. There was an inverse association between baked poultry and advanced prostate cancer.

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Risk factors for delirium post-radical cystectomy

Researchers at the University of Chicago Pritzker School of Medicine have reported that older age and the pre-operative MMSE results are associated with post-radical cystectomy (OR = 1.52) in patients > 65 years of age (n=49). The incidence of post-operative delirium was 29%. Further, patients with post-operative delirium were at increased risk for readmission (OR = 10.7) and re-operation (OR = 9.2).

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PSA screening reduces risk of metastatic cancer of the prostate

As published in European Neurology, men (age range, 55-69 years) who undergo PSA screening are at decreased risk for metastatic cancer of the prostate. The study involved 76,813 men with a median follow-up of 12 y. There were 666 cases with metastatic cancer of the prostate(256 screened [.67%/1000] and 410 non-screened [.86%/1000]). The HR for men who were screened was 0.58.

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Urology - Clinical Pharmacology News & Articles

Articles

Prior Articles

Clinical Pearls in Urology

Highlights in Urology

Red meat cooked at high temperatures increases risk of advanced cancer of the prostate

Risk factors for delirium post-radical cystectomy

PSA screening reduces risk of metastatic cancer of the prostate

Most Popular Urology Articles

Other Topics in Urology