Urology - Clinical Pharmacology News & Articles

Now available on MDLinx Urology, find daily updates summarizing the top literature from over 2,000 peer-reviewed journals, including Journal of Urology, European Urology, The Prostate, and more. Find coverage of the kidney, bladder, penis/urethra and prostate. View article summaries by subspecialty and disease state, including peds urology, urologic oncology, stone disease, infections and STDs, urologic imaging, ureteral disease, voiding and incontinence, infertility, laparoscopy and other surgical techniques, and additional hot topics in your field. Find exclusive content only available on MDLinx Urology like articles highlighted by physician editor D. Scott Cunningham, MD, PhD, and clinical pearls gleaned from The Smartest Doc quiz competitions and Physician Reviews.

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Latest (2) Full Text Articles (71)

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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1 A phase II trial of neoadjuvant nab-paclitaxel, carboplatin, and gemcitabine (ACAG) in patients with locally advanced carcinoma of the bladder Urology, May 24, 2013 Clinical Article

2 NF-kappaB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants Molecular Cancer Therapeutics, May 24, 2013 Clinical Article

Prior Articles

3 Nanoparticle albumin-bound paclitaxel for second-line treatment of metastatic urothelial carcinoma: a single group, multicentre, phase 2 study The Lancet Oncology, May 23, 2013 Clinical Article

4 Cardiovascular risk and bone loss in men undergoing androgen deprivation therapy for non-metastatic prostate cancer: implementation of standardized management guidelines Journal of Andrology, May 22, 2013 Clinical Article

5 Carboplatin AUC 10 for IGCCCG good prognosis metastatic seminoma Acta Oncologica, May 22, 2013 Clinical Article

6 Antimitotic agents for the treatment of patients with metastatic castrate-resistant prostate cancer Expert Opinion on Investigational Drugs, May 21, 2013 Review Article

7 Current pharmacological treatment options for male lower urinary tract symptoms Expert Opinion on Pharmacotherapy, May 21, 2013 Clinical Article

8 Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism Cancer Research, May 20, 2013 Clinical Article

9 Efficacy of Sotrastaurin Plus Tacrolimus After De Novo Kidney Transplantation: Randomized, Phase II Trial Results American Journal of Transplantation, May 20, 2013 Clinical Article

10 A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases Clinical Cancer Research, May 17, 2013 Clinical Article

11 Prescription Opioids for Back Pain and Use of Medications for Erectile Dysfunction Spine, May 17, 2013 Evidence Based Medicine Clinical Article

12 Cephalothin susceptibility testing as class representative for oral cephalosporins: is it time to move on Diagnostic Microbiology and Infectious Disease, May 17, 2013 Clinical Article

13 A phase 3, placebo controlled study of the safety and efficacy of avanafil for the treatment of erectile dysfunction after nerve sparing radical prostatectomy The Journal of Urology, May 16, 2013 Clinical Article

14 Evaluation of Mycophenolic Acid Exposure Using a Limited Sampling Strategy in Renal Transplant Recipients American Journal of Nephrology, May 15, 2013 Clinical Article

15 Basiliximab induction in renal transplantation: Long-term outcome Full Text Saudi Journal of Kidney Diseases and Transplantation, May 14, 2013 Clinical Article

16 Image-directed, tissue-preserving focal therapy of prostate cancer: a feasibility study of a novel deformable MR-US registration system BJU International, May 13, 2013 Clinical Article

17 Optimization of initial prostate biopsy in clinical practice: sampling, labeling and specimen processing The Journal of Urology, May 13, 2013 Review Article

18 Intraurethral tramadol alleviates rigid cystoscopy-related pain in men International Journal of Urological Nursing, May 13, 2013 Clinical Article

19 A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer Investigational New Drugs, May 7, 2013 Clinical Article

20 Platinum-Based Chemotherapy for Variant Castrate-Resistant Prostate Cancer Clinical Cancer Research, May 7, 2013 Clinical Article

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Clinical Pearls in Urology

Because temozolomide is associated with changes in male fertility, consider referring patients for sperm banking prior to initiating chemotherapy for glioblastoma multiforme (GBM)
The schedule of radium-223 used in the ALSYMPCA trial is 5 minute infusion every 4 weeks x6 doses. Given in this fashion, it significantly improved median OS, time to SRE and time to PSA progression in men with advanced cancer of the prostate without demonstrable side effects
In RTOG 94-08 the addition of short course androgen deprivation to radiation therapy for men with intermediate risk cancer of the prostate resulted in a 50% reduction in disease specific mortality at 10-years

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Highlights in Urology

Red meat cooked at high temperatures increases risk of advanced cancer of the prostate

Researchers at the University of Southern California have reported a risk between advanced cancer of the prostate and red meats cooked at high temperature, pan-frying, and prepared "well done." The study involved 1140 men with advanced cancer of the prostate, 717 men with localized cancer of the prostate, and 1096 healthy controls from the California Collaborative Prostate Cancer Study. There was an inverse association between baked poultry and advanced prostate cancer.

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Risk factors for delirium post-radical cystectomy

Researchers at the University of Chicago Pritzker School of Medicine have reported that older age and the pre-operative MMSE results are associated with post-radical cystectomy (OR = 1.52) in patients > 65 years of age (n=49). The incidence of post-operative delirium was 29%. Further, patients with post-operative delirium were at increased risk for readmission (OR = 10.7) and re-operation (OR = 9.2).

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PSA screening reduces risk of metastatic cancer of the prostate

As published in European Neurology, men (age range, 55-69 years) who undergo PSA screening are at decreased risk for metastatic cancer of the prostate. The study involved 76,813 men with a median follow-up of 12 y. There were 666 cases with metastatic cancer of the prostate(256 screened [.67%/1000] and 410 non-screened [.86%/1000]). The HR for men who were screened was 0.58.

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Last month's top read Top Articles of 2012

1 Effect of dutasteride on clinical progression of benign prostatic hyperplasia in asymptomatic men with enlarged prostate: a post hoc analysis of the REDUCE study British Medical Journal, April 23, 2013

2 Balanitis xerotica obliterans, the topical application of tacrolimus ointment, and the result: an institutional study UroToday International Journal, April 15, 2013

3 Results of a randomized phase III trial of mirabegron in patients with overactive bladder The Journal of Urology, April 8, 2013

4 Statin use and risk of prostate cancer and high-grade prostate cancer: results from the REDUCE study Prostate Cancer & Prostatic Diseases, April 11, 2013

5 Prospective randomized placebo-controlled study to assess the safety and efficacy of silodosin in the management of acute urinary retention Urology, April 9, 2013

6 STAT3 polymorphism can predict the response to interferon-α therapy in patients with metastatic renal cell carcinoma European Urology, April 5, 2013 Free full text

7 Abiraterone and Novel Antiandrogens: Overcoming Castration Resistance in Prostate Cancer Annual Review of Medicine, April 26, 2013 Review Article

8 Lower baseline prostate-specific antigen is associated with a greater overall survival benefit from sipuleucel-t in the immunotherapy for prostate adenocarcinoma treatment (impact) trial Urology, April 12, 2013

9 Simvastatin induces apoptosis in castrate resistant prostate cancer cells by deregulating nuclear factor-κb pathway The Journal of Urology, April 12, 2013

10 Amphotericin B bladder irrigation for the treatment of neonatal bladder fungus ball Journal of Pediatric Infectious Diseases, April 15, 2013

11 A phase II trial of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for local failures or advanced prostate cancer Cancer Chemotherapy and Pharmacology, April 22, 2013

12 Peironimev-Plus in the Treatment of Chronic Inflammation of Tunica Albuginea (Peyronies Disease). Results of a Controlled Study Inflammation & Allergy - Drug Targets, April 9, 2013

13 Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): Results from a phase I-II clinical trial Urologic Oncology: Seminars and Original Investigations, March 26, 2013

14 Prevalence of patients with nonmetastatic prostate cancer on androgen deprivation therapy in the United States Urology, April 19, 2013

15 Botulinum toxin-A for the treatment of overactive bladder: UK contributions Journal of Clinical Urology, April 10, 2013

16 Terpene compound drug as medical expulsive therapy for ureterolithiasis: a meta-analysis Urological Research - Urolithiasis, April 2, 2013

17 A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases Clinical Cancer Research, April 4, 2013

18 Randomized controlled trial to assess the efficacy of the combination therapy of alfuzosin and tadalafil in patients with lower urinary tract symptoms due to benign prostatic hyperplasia LUTS: Lower Urinary Tract Symptoms, April 5, 2013

19 Does tamsulosin change the management of proximally located ureteral stones? Urological Research - Urolithiasis, March 1, 2010

20 Urolithiasis in patients on high dose felbamate The Journal of Urology, April 16, 2013 Review Article

Indexed Journals in Urology: Urology, Journal of Urology, European Urology, The Prostate more

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Urology - Clinical Pharmacology News & Articles

Articles

Prior Articles

Clinical Pearls in Urology

Highlights in Urology

Red meat cooked at high temperatures increases risk of advanced cancer of the prostate

Risk factors for delirium post-radical cystectomy

PSA screening reduces risk of metastatic cancer of the prostate

Most Popular Urology Articles

Other Topics in Urology