Urology - Clinical Pharmacology News & Articles

Now available on MDLinx Urology, find daily updates summarizing the top literature from over 2,000 peer-reviewed journals, including Journal of Urology, European Urology, The Prostate, and more. Find coverage of the kidney, bladder, penis/urethra and prostate. View article summaries by subspecialty and disease state, including peds urology, urologic oncology, stone disease, infections and STDs, urologic imaging, ureteral disease, voiding and incontinence, infertility, laparoscopy and other surgical techniques, and additional hot topics in your field. Find exclusive content only available on MDLinx Urology like articles highlighted by physician editor D. Scott Cunningham, MD, PhD, and clinical pearls gleaned from The Smartest Doc quiz competitions and Physician Reviews.

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Latest (2) Full Text Articles (71)

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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81 The use of eculizumab in renal transplantation Clinical Transplantation, March 28, 2013 Review Article

82 Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality Full Text European Urology, March 27, 2013 Clinical Article

83 Oxacillin resistance and antimicrobial susceptibility profile of staphylococcussaprophyticus and other staphylococci isolated from patients with urinary tract infection Chemotherapy, March 27, 2013 Clinical Article

84 Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): Results from a phase I-II clinical trial Urologic Oncology: Seminars and Original Investigations, March 26, 2013 Clinical Article

85 Antibiotic treatment of urinary tract infection by community pharmacists: a cross-sectional study British Journal of General Practice, March 25, 2013 Clinical Article

86 Solifenacin improves double-J stent-related symptoms in both genders following uncomplicated ureteroscopic lithotripsy Urological Research - Urolithiasis, March 22, 2013 Clinical Article

87 A Diagnostic Conundrum: Acute Interstitial Nephritis due to Armodafinil Versus Acute Cellular Rejection in a Renal Transplant Recipient--A Case Report Transplantation Proceedings, March 22, 2013 Clinical Article

88 Prostate-specific antigen response after short-term hormone therapy plus external-beam radiotherapy and outcome in patients treated on Radiation Therapy Oncology Group study 9413 Cancer, March 20, 2013 Clinical Article

89 Effect of morphine on lower urinary tract discomfort after transurethral resection of prostate under general anesthesia: a randomised clinical study Journal of Anesthesia, March 20, 2013 Clinical Article

90 Multi-institutional analysis of sequential intravesical gemcitabine and mitomycin C chemotherapy for non–muscle invasive bladder cancer Urologic Oncology: Seminars and Original Investigations, March 20, 2013 Review Article Clinical Article

91 Intravenous Pamidronate in the Treatment of Severe Idiopathic Infantile Hypercalcemia Iranian Journal of Kidney Diseases, March 20, 2013 Clinical Article

92 Could testosterone have a therapeutic role in prostate cancer? Full Text Urology Journal, March 19, 2013 Clinical Article

93 Treatment options in castration-resistant prostate cancer: Current therapies and emerging docetaxel-based regimens Urologic Oncology: Seminars and Original Investigations, March 19, 2013 Clinical Article

94 Phase II Trial Assessing Granulocyte-macrophage-Colony Stimulating Factor, Ketoconazole Plus Mitoxantrone in Metastatic Castration-resistant Prostate Cancer Progressing After Docetaxel Treatments Cancer Investigation, March 19, 2013 Clinical Article

95 The effect of testosterone on mood and well-being in men with erectile dysfunction in a randomized, placebo-controlled trial Journal of Andrology, March 19, 2013 Clinical Article

96 Prostaglandin receptor EP3 mediates growth inhibitory effect of aspirin through androgen receptor and contributes to castration resistance in prostate cancer ells Endocrine-Related Cancer, March 19, 2013 Review Article

97 Does routine prophylactic oral flucloxacillin reduce the incidence of post-circumcision infections American Journal of Infection Control, March 19, 2013 Clinical Article

98 A phase II dose-ranging study of mirabegron in patients with overactive bladder International Urogynecology Journal, March 18, 2013 Clinical Article

99 Predictors of depression, anxiety and quality of life in patients with prostate cancer receiving androgen deprivation therapy Psycho-Oncology, March 15, 2013 Clinical Article

100 Osteoporosis management program decreases incidence of hip fracture in patients with prostate cancer receiving androgen deprivation therapy Urology, March 15, 2013 Clinical Article

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Clinical Pearls in Urology

Because temozolomide is associated with changes in male fertility, consider referring patients for sperm banking prior to initiating chemotherapy for glioblastoma multiforme (GBM)
The schedule of radium-223 used in the ALSYMPCA trial is 5 minute infusion every 4 weeks x6 doses. Given in this fashion, it significantly improved median OS, time to SRE and time to PSA progression in men with advanced cancer of the prostate without demonstrable side effects
In RTOG 94-08 the addition of short course androgen deprivation to radiation therapy for men with intermediate risk cancer of the prostate resulted in a 50% reduction in disease specific mortality at 10-years

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Highlights in Urology

Red meat cooked at high temperatures increases risk of advanced cancer of the prostate

Researchers at the University of Southern California have reported a risk between advanced cancer of the prostate and red meats cooked at high temperature, pan-frying, and prepared "well done." The study involved 1140 men with advanced cancer of the prostate, 717 men with localized cancer of the prostate, and 1096 healthy controls from the California Collaborative Prostate Cancer Study. There was an inverse association between baked poultry and advanced prostate cancer.

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Risk factors for delirium post-radical cystectomy

Researchers at the University of Chicago Pritzker School of Medicine have reported that older age and the pre-operative MMSE results are associated with post-radical cystectomy (OR = 1.52) in patients > 65 years of age (n=49). The incidence of post-operative delirium was 29%. Further, patients with post-operative delirium were at increased risk for readmission (OR = 10.7) and re-operation (OR = 9.2).

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PSA screening reduces risk of metastatic cancer of the prostate

As published in European Neurology, men (age range, 55-69 years) who undergo PSA screening are at decreased risk for metastatic cancer of the prostate. The study involved 76,813 men with a median follow-up of 12 y. There were 666 cases with metastatic cancer of the prostate(256 screened [.67%/1000] and 410 non-screened [.86%/1000]). The HR for men who were screened was 0.58.

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Most Popular Urology Articles

Last month's top read Top Articles of 2012

1 Effect of dutasteride on clinical progression of benign prostatic hyperplasia in asymptomatic men with enlarged prostate: a post hoc analysis of the REDUCE study British Medical Journal, April 23, 2013

2 Balanitis xerotica obliterans, the topical application of tacrolimus ointment, and the result: an institutional study UroToday International Journal, April 15, 2013

3 Results of a randomized phase III trial of mirabegron in patients with overactive bladder The Journal of Urology, April 8, 2013

4 Statin use and risk of prostate cancer and high-grade prostate cancer: results from the REDUCE study Prostate Cancer & Prostatic Diseases, April 11, 2013

5 Prospective randomized placebo-controlled study to assess the safety and efficacy of silodosin in the management of acute urinary retention Urology, April 9, 2013

6 STAT3 polymorphism can predict the response to interferon-α therapy in patients with metastatic renal cell carcinoma European Urology, April 5, 2013 Free full text

7 Abiraterone and Novel Antiandrogens: Overcoming Castration Resistance in Prostate Cancer Annual Review of Medicine, April 26, 2013 Review Article

8 Lower baseline prostate-specific antigen is associated with a greater overall survival benefit from sipuleucel-t in the immunotherapy for prostate adenocarcinoma treatment (impact) trial Urology, April 12, 2013

9 Simvastatin induces apoptosis in castrate resistant prostate cancer cells by deregulating nuclear factor-κb pathway The Journal of Urology, April 12, 2013

10 Amphotericin B bladder irrigation for the treatment of neonatal bladder fungus ball Journal of Pediatric Infectious Diseases, April 15, 2013

11 A phase II trial of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for local failures or advanced prostate cancer Cancer Chemotherapy and Pharmacology, April 22, 2013

12 Peironimev-Plus in the Treatment of Chronic Inflammation of Tunica Albuginea (Peyronies Disease). Results of a Controlled Study Inflammation & Allergy - Drug Targets, April 9, 2013

13 Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): Results from a phase I-II clinical trial Urologic Oncology: Seminars and Original Investigations, March 26, 2013

14 Prevalence of patients with nonmetastatic prostate cancer on androgen deprivation therapy in the United States Urology, April 19, 2013

15 Botulinum toxin-A for the treatment of overactive bladder: UK contributions Journal of Clinical Urology, April 10, 2013

16 Terpene compound drug as medical expulsive therapy for ureterolithiasis: a meta-analysis Urological Research - Urolithiasis, April 2, 2013

17 A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases Clinical Cancer Research, April 4, 2013

18 Randomized controlled trial to assess the efficacy of the combination therapy of alfuzosin and tadalafil in patients with lower urinary tract symptoms due to benign prostatic hyperplasia LUTS: Lower Urinary Tract Symptoms, April 5, 2013

19 Does tamsulosin change the management of proximally located ureteral stones? Urological Research - Urolithiasis, March 1, 2010

20 Urolithiasis in patients on high dose felbamate The Journal of Urology, April 16, 2013 Review Article

Indexed Journals in Urology: Urology, Journal of Urology, European Urology, The Prostate more

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Urology - Clinical Pharmacology News & Articles

Articles

Clinical Pearls in Urology

Highlights in Urology

Red meat cooked at high temperatures increases risk of advanced cancer of the prostate

Risk factors for delirium post-radical cystectomy

PSA screening reduces risk of metastatic cancer of the prostate

Most Popular Urology Articles

Other Topics in Urology