Urology - Basic Science/Genetics News & Articles

Now available on MDLinx Urology, find daily updates summarizing the top literature from over 2,000 peer-reviewed journals, including Journal of Urology, European Urology, The Prostate, and more. Find coverage of the kidney, bladder, penis/urethra and prostate. View article summaries by subspecialty and disease state, including peds urology, urologic oncology, stone disease, infections and STDs, urologic imaging, ureteral disease, voiding and incontinence, infertility, laparoscopy and other surgical techniques, and additional hot topics in your field. Find exclusive content only available on MDLinx Urology like articles highlighted by physician editor D. Scott Cunningham, MD, PhD, and clinical pearls gleaned from The Smartest Doc quiz competitions and Physician Reviews.

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Latest (3) Full Text Articles (29)

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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121 Novel Mutation Among Two Sisters With 17β Hydroxysteroid Dehydrogenase Type 3 Deficiency Urology, February 1, 2013

122 Assessment of sperm hyperactivated motility and acrosome reaction can discriminate the use of spermatozoa for conventional in vitro fertilisation or intracytoplasmic sperm injection: Preliminary results Andrologia, February 1, 2013 Review Article

123 Cigarette smoke condensate induces aryl hydrocarbon receptor-dependent changes in gene expression in spermatocytes Reproductive Toxicology, January 31, 2013 Review Article

124 Expression and functional role of β3-adrenoceptors in the human ureter International Journal of Urology, January 31, 2013 Review Article

125 Sperm speed is associated with sex bias of siblings in a human population Full Text Asian Journal of Andrology, January 31, 2013 Review Article

126 Microdissection testicular sperm extraction: an update Full Text Asian Journal of Andrology, January 31, 2013 Review Article

127 A significant effect of the TSPY1 copy number on spermatogenesis efficiency and the phenotypic expression of the gr/gr deletion Human Molecular Genetics, January 31, 2013 Review Article

128 Proteus: Mythology to modern times Full Text Indian Journal of Urology, January 31, 2013 Review Article

129 Involvement of KLF14 and egr-1 in the TGF-β1 action on Leydig cell proliferation Cytokine, January 31, 2013 Review Article

130 Impact of HLA-G 14-bp polymorphism on acute rejection and cytomegalovirus infection in kidney transplant recipients from northwestern China Transplant Immunology, January 31, 2013 Review Article

131 Effect of quercetin, rutin, naringenin and epicatechin on lipid peroxidation induced in human sperm Reproductive Toxicology, January 31, 2013 Review Article

132 The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity Reproductive Toxicology, January 31, 2013 Review Article

133 Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland Reproductive Toxicology, January 31, 2013 Review Article

134 Identification of sperm head proteins involved in zona pellucida binding Human Reproduction, January 31, 2013 Review Article

135 Factors influencing intracytoplasmic sperm injection (ICSI) outcome in men with azoospermia BJU International, January 30, 2013 Review Article

136 Expression of β-Adrenoceptor Subtypes in Urothelium, Interstitial Cells and Detrusor of the Human Urinary Bladder LUTS: Lower Urinary Tract Symptoms, January 29, 2013 Review Article

137 LIGHT/HVEM/LTβR Interaction as a Target for the Modulation of the Allogeneic Immune Response in Transplantation American Journal of Transplantation, January 29, 2013 Review Article

138 MiR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells International Journal of Cancer, January 28, 2013 Clinical Article

139 In Vitro Examination of Effects of Hyperprolactinemia and Hypoprolactinemia on Seminal Vesicle Contractions Urology, January 28, 2013 Review Article

140 Loss of SPARC in bladder cancer enhances carcinogenesis and progression Full Text The Journal of Clinical Investigation, January 25, 2013 Clinical Article

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Clinical Pearls in Urology

Because temozolomide is associated with changes in male fertility, consider referring patients for sperm banking prior to initiating chemotherapy for glioblastoma multiforme (GBM)
The schedule of radium-223 used in the ALSYMPCA trial is 5 minute infusion every 4 weeks x6 doses. Given in this fashion, it significantly improved median OS, time to SRE and time to PSA progression in men with advanced cancer of the prostate without demonstrable side effects
In RTOG 94-08 the addition of short course androgen deprivation to radiation therapy for men with intermediate risk cancer of the prostate resulted in a 50% reduction in disease specific mortality at 10-years

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Highlights in Urology

Red meat cooked at high temperatures increases risk of advanced cancer of the prostate

Researchers at the University of Southern California have reported a risk between advanced cancer of the prostate and red meats cooked at high temperature, pan-frying, and prepared "well done." The study involved 1140 men with advanced cancer of the prostate, 717 men with localized cancer of the prostate, and 1096 healthy controls from the California Collaborative Prostate Cancer Study. There was an inverse association between baked poultry and advanced prostate cancer.

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Risk factors for delirium post-radical cystectomy

Researchers at the University of Chicago Pritzker School of Medicine have reported that older age and the pre-operative MMSE results are associated with post-radical cystectomy (OR = 1.52) in patients > 65 years of age (n=49). The incidence of post-operative delirium was 29%. Further, patients with post-operative delirium were at increased risk for readmission (OR = 10.7) and re-operation (OR = 9.2).

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PSA screening reduces risk of metastatic cancer of the prostate

As published in European Neurology, men (age range, 55-69 years) who undergo PSA screening are at decreased risk for metastatic cancer of the prostate. The study involved 76,813 men with a median follow-up of 12 y. There were 666 cases with metastatic cancer of the prostate(256 screened [.67%/1000] and 410 non-screened [.86%/1000]). The HR for men who were screened was 0.58.

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Most Popular Urology Articles

Last month's top read Top Articles of 2012

1 Routine urine cytology has no role in hematuria investigations The Journal of Urology, April 18, 2013

2 A retrospective study of clinical outcomes of alpha-blocker or finasteride monotherapy followed by combination therapy: determination of the period of combination therapy of -alpha blocker and finasteride International Journal of Clinical Practice, April 9, 2013

3 Abiraterone and Novel Antiandrogens: Overcoming Castration Resistance in Prostate Cancer Annual Review of Medicine, April 26, 2013 Review Article

4 Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Crossover Study Gynecologic and Obstetric Investigation, April 12, 2013

5 Pleasure and Pain: The Effect of (Almost) Having an Orgasm on Genital and Nongenital Sensitivity The Journal of Sexual Medicine, April 23, 2013 Review Article

6 Effect of intrinsic sphincter deficiency on midurethral sling outcomes in women with mixed urinary incontinence Female Pelvic Medicine & Reconstructive Surgery, April 26, 2013

7 Screening for Prostate Cancer: A Guidance Statement From the Clinical Guidelines Committee of the American College of Physicians Annals of Internal Medicine, April 10, 2013 Clinical Guideline

8 Independent Cellular Effects of Cold Ischemia and Reperfusion: Experimental Molecular Study Transplantation Proceedings, April 29, 2013 Review Article

9 Anterior urethral stricture review Translational Andrology and Urology, April 4, 2013 Free full text Review Article

10 An open-label, long-term evaluation of the safety, efficacy and tolerability of avanafil in male patients with mild to severe erectile dysfunction International Journal of Clinical Practice, April 9, 2013

11 Smoking status modifies the relation between cyp1a1*2c gene polymorphism and idiopathic male infertility the importance of gene–environment interaction analysis for genetic studies of the disease Reproductive Sciences, April 9, 2013

12 Brg1 Determines Urothelial Cell Fate during Ureter Development Journal of the American Society of Nephrology, March 1, 2013 Review Article

13 Erectile dysfunction in the cardiovascular patient European Heart Journal, April 29, 2013

14 Severity of Urinary Incontinence and Effect on Quality of Life in Women by Incontinence Type Obstetrics and Gynecology, April 26, 2013

15 The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis Journal of Andrology, April 1, 2013

16 Expression of CX3CR1 associates with cellular migration, metastasis, and prognosis in human clear cell renal cell carcinoma Urologic Oncology: Seminars and Original Investigations, April 26, 2013

17 Early and Complete Excision of Vaginally Placed Synthetic Mesh Female Pelvic Medicine & Reconstructive Surgery, April 26, 2013

18 Sperm motility and DNA integrity affected by different g-forces in the preparation of sperm in urine specimens Andrologia, April 5, 2013

19 Location and Characterization of GAPDS in Male Reproduction Urologia Internationalis, February 4, 2013 Review Article

20 Genes associated with prostate cancer are differentially expressed in African American and European American men Cancer Epidemiology, Biomarkers & Prevention, March 26, 2013 Review Article

Indexed Journals in Urology: Urology, Journal of Urology, European Urology, The Prostate more

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Urology - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Urology

Highlights in Urology

Red meat cooked at high temperatures increases risk of advanced cancer of the prostate

Risk factors for delirium post-radical cystectomy

PSA screening reduces risk of metastatic cancer of the prostate

Most Popular Urology Articles

Other Topics in Urology