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Urology - Basic Science/Genetics News & Articles
Now available on MDLinx Urology, find daily updates summarizing the top literature from over 2,000 peer-reviewed journals, including Journal of Urology, European Urology, The Prostate, and more. Find coverage of the kidney, bladder, penis/urethra and prostate. View article summaries by subspecialty and disease state, including peds urology, urologic oncology, stone disease, infections and STDs, urologic imaging, ureteral disease, voiding and incontinence, infertility, laparoscopy and other surgical techniques, and additional hot topics in your field. Find exclusive content only available on MDLinx Urology like articles highlighted by physician editor D. Scott Cunningham, MD, PhD, and clinical pearls gleaned from The Smartest Doc quiz competitions and Physician Reviews.
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Latest Full Text Articles (29)561 A Case of Prostatic Adenocarcinoma With Aberrant p63 Expression: Presentation With Detailed Immunohistochemical Study and FISH Analysis International Journal of Surgical Pathology, February 11, 2011
562 Expression of SLCO transport genes in castration resistant prostate cancer and impact of genetic variation in SCLO1B3 and SLCO2B1 on prostate cancer outcomes Cancer Epidemiology, Biomarkers & Prevention, February 9, 2011
563 Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles–Shanghai bladder case–control study Carcinogenesis, February 9, 2011
564 Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C British Journal of Cancer, February 9, 2011
565 Prognostic value of opioid binding protein/cell adhesion molecule-like promoter methylation in bladder carcinoma European Journal of Cancer, February 7, 2011
566 Primary Intratesticular Spindle Cell Tumors: Interdigitating Dendritic Cell Tumor and Inflammatory Myofibroblastic Tumor International Journal of Surgical Pathology, February 7, 2011
567 Beta-arrestin-2 is expressed in human prostate smooth muscle and a binding partner of alpha-1A-adrenoceptors World Journal of Urology, February 3, 2011
568 Simulating calcium salt precipitation in the nephron using chemical speciation Urological Research - Urolithiasis, February 3, 2011
569 WT1-specific CTL cells of recipient origin may exist in the peripheral blood of patients achieving full donor chimerism soon after nonmyeloablative transplantation Clinical Transplantation, February 3, 2011
570 Lack of association of IL-10 gene polymorphisms with prostate cancer: Evidence from 11,581 subjects European Journal of Cancer, February 2, 2011
571 I-kappa-B-Kinase-epsilon (IKK-epsilon/IKKi/I-kappa-BK-epsilon) expression and localization in prostate cancer tissues The Prostate, February 2, 2011
572 Anticancer efficacy of deguelin in human prostate cancer cells targeting GSK-3-beta/beta-catenin pathway International Journal of Cancer, February 1, 2011
573 46,XY pure gonadal dysgenesis: Clinical presentations and management of the tumor risk Journal of Pediatric Urology, January 31, 2011
574 Clinical and laboratory features of Macedonian children with OCRL mutations Pediatric Nephrology, January 28, 2011
575 Role of TP53 Arg72Pro polymorphism in urinary bladder cancer predisposition and predictive impact of proline related genotype in advanced tumors in an ethnic Kashmiri population Cancer Genetics, January 27, 2011
576 HMOX1 is an Important Prognostic Indicator of Nonmuscle Invasive Bladder Cancer Recurrence and Progression The Journal of Urology, January 25, 2011
577 MicroRNA-616 Induces Androgen-Independent Growth of Prostate Cancer Cells by Suppressing Expression of Tissue Factor Pathway Inhibitor TFPI-2 Full Text Cancer Research, January 25, 2011
578 Predicting HLA Class II Alloantigen Immunogenicity From the Number and Physiochemical Properties of Amino Acid Polymorphisms Transplantation, January 24, 2011
579 Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility Molecular Human Reproduction, January 24, 2011
580 Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran Prostate Cancer & Prostatic Diseases, January 20, 2011
Clinical Pearls in Urology
- Because temozolomide is associated with changes in male fertility, consider referring patients for sperm banking prior to initiating chemotherapy for glioblastoma multiforme (GBM)
- The schedule of radium-223 used in the ALSYMPCA trial is 5 minute infusion every 4 weeks x6 doses. Given in this fashion, it significantly improved median OS, time to SRE and time to PSA progression in men with advanced cancer of the prostate without demonstrable side effects
- In RTOG 94-08 the addition of short course androgen deprivation to radiation therapy for men with intermediate risk cancer of the prostate resulted in a 50% reduction in disease specific mortality at 10-years
Highlights in Urology
Red meat cooked at high temperatures increases risk of advanced cancer of the prostate
Researchers at the University of Southern California have reported a risk between advanced cancer of the prostate and red meats cooked at high temperature, pan-frying, and prepared "well done." The study involved 1140 men with advanced cancer of the prostate, 717 men with localized cancer of the prostate, and 1096 healthy controls from the California Collaborative Prostate Cancer Study. There was an inverse association between baked poultry and advanced prostate cancer.
Read the article summaryRisk factors for delirium post-radical cystectomy
Researchers at the University of Chicago Pritzker School of Medicine have reported that older age and the pre-operative MMSE results are associated with post-radical cystectomy (OR = 1.52) in patients > 65 years of age (n=49). The incidence of post-operative delirium was 29%. Further, patients with post-operative delirium were at increased risk for readmission (OR = 10.7) and re-operation (OR = 9.2).
Read the article summaryPSA screening reduces risk of metastatic cancer of the prostate
As published in European Neurology, men (age range, 55-69 years) who undergo PSA screening are at decreased risk for metastatic cancer of the prostate. The study involved 76,813 men with a median follow-up of 12 y. There were 666 cases with metastatic cancer of the prostate(256 screened [.67%/1000] and 410 non-screened [.86%/1000]). The HR for men who were screened was 0.58.
Read the article summaryMost Popular Urology Articles
Last month's top read Top Articles of 20121 Routine urine cytology has no role in hematuria investigations The Journal of Urology, April 18, 2013
2 A retrospective study of clinical outcomes of alpha-blocker or finasteride monotherapy followed by combination therapy: determination of the period of combination therapy of -alpha blocker and finasteride International Journal of Clinical Practice, April 9, 2013
3 Abiraterone and Novel Antiandrogens: Overcoming Castration Resistance in Prostate Cancer Annual Review of Medicine, April 26, 2013 Review Article
4 Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Crossover Study Gynecologic and Obstetric Investigation, April 12, 2013
5 Pleasure and Pain: The Effect of (Almost) Having an Orgasm on Genital and Nongenital Sensitivity The Journal of Sexual Medicine, April 23, 2013 Review Article
6 Effect of intrinsic sphincter deficiency on midurethral sling outcomes in women with mixed urinary incontinence Female Pelvic Medicine & Reconstructive Surgery, April 26, 2013
7 Screening for Prostate Cancer: A Guidance Statement From the Clinical Guidelines Committee of the American College of Physicians Annals of Internal Medicine, April 10, 2013 Clinical Guideline
8 Independent Cellular Effects of Cold Ischemia and Reperfusion: Experimental Molecular Study Transplantation Proceedings, April 29, 2013 Review Article
9 Anterior urethral stricture review Translational Andrology and Urology, April 4, 2013 Free full text Review Article
10 An open-label, long-term evaluation of the safety, efficacy and tolerability of avanafil in male patients with mild to severe erectile dysfunction International Journal of Clinical Practice, April 9, 2013
11 Smoking status modifies the relation between cyp1a1*2c gene polymorphism and idiopathic male infertility the importance of gene–environment interaction analysis for genetic studies of the disease Reproductive Sciences, April 9, 2013
12 Brg1 Determines Urothelial Cell Fate during Ureter Development Journal of the American Society of Nephrology, March 1, 2013 Review Article
13 Erectile dysfunction in the cardiovascular patient European Heart Journal, April 29, 2013
14 Severity of Urinary Incontinence and Effect on Quality of Life in Women by Incontinence Type Obstetrics and Gynecology, April 26, 2013
15 The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis Journal of Andrology, April 1, 2013
16 Expression of CX3CR1 associates with cellular migration, metastasis, and prognosis in human clear cell renal cell carcinoma Urologic Oncology: Seminars and Original Investigations, April 26, 2013
17 Early and Complete Excision of Vaginally Placed Synthetic Mesh Female Pelvic Medicine & Reconstructive Surgery, April 26, 2013
18 Sperm motility and DNA integrity affected by different g-forces in the preparation of sperm in urine specimens Andrologia, April 5, 2013
19 Location and Characterization of GAPDS in Male Reproduction Urologia Internationalis, February 4, 2013 Review Article
20 Genes associated with prostate cancer are differentially expressed in African American and European American men Cancer Epidemiology, Biomarkers & Prevention, March 26, 2013 Review Article
Indexed Journals in Urology: Urology, Journal of Urology, European Urology, The Prostate more
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