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Urology - Basic Science/Genetics News & Articles
Now available on MDLinx Urology, find daily updates summarizing the top literature from over 2,000 peer-reviewed journals, including Journal of Urology, European Urology, The Prostate, and more. Find coverage of the kidney, bladder, penis/urethra and prostate. View article summaries by subspecialty and disease state, including peds urology, urologic oncology, stone disease, infections and STDs, urologic imaging, ureteral disease, voiding and incontinence, infertility, laparoscopy and other surgical techniques, and additional hot topics in your field. Find exclusive content only available on MDLinx Urology like articles highlighted by physician editor D. Scott Cunningham, MD, PhD, and clinical pearls gleaned from The Smartest Doc quiz competitions and Physician Reviews.
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Articles
Latest (3) Full Text Articles (29)181 Complete remission with tyrosine kinase inhibitors in renal cell carcinoma Full Text Translational Andrology and Urology, December 24, 2012
182 The Mitochondria-Targeted Antioxidants and Remote Kidney Preconditioning Ameliorate Brain Damage through Kidney-to-Brain Cross-Talk PLOS ONE, December 21, 2012
183 Sperm DNA fragmentation in couples with unexplained recurrent spontaneous abortions Andrologia, December 21, 2012
184 Antiandrogenic Activity of Resveratrol Analogs in Prostate Cancer LNCaP Cells Journal of Andrology, December 20, 2012
185 Prostate specific membrane antigen (PSMA): A novel modulator of p38 for proliferation, migration, and survival in prostate cancer cells The Prostate, December 20, 2012
186 TRPM8 Ion Channels Differentially Modulate Proliferation and Cell Cycle Distribution of Normal and Cancer Prostate Cells PLOS ONE, December 20, 2012
187 Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells Nephrology Dialysis Transplantation, December 20, 2012
188 Arterial Erectile Dysfunction and Peripheral Arterial Disease: Reliability of a New Phenotype of Endothelial Progenitor Cells and Endothelial Microparticles Journal of Andrology, December 20, 2012
189 Nandrolone, an Anabolic Steroid, Stabilizes Numb Protein Through Inhibition of mdm2 in C2C12 Myoblasts Journal of Andrology, December 20, 2012
190 Receptor-Recognized α2-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells PLOS ONE, December 19, 2012
191 Differential expression of mRNA aromatase in ejaculated spermatozoa from infertile men in relation to either asthenozoospermia or teratozoospermia Andrologia, December 19, 2012
192 Cryopreservation of Human Spermatozoa Decreases the Number of Motile Normal Spermatozoa, Induces Nuclear Vacuolization and Chromatin Decondensation Journal of Andrology, December 19, 2012
193 Association Between Sex Steroid Hormones and Hematocrit in a Nationally Representative Sample of Men Journal of Andrology, December 19, 2012
194 Low Amounts and High Thiol Oxidation of Peroxiredoxins in Spermatozoa From Infertile Men Journal of Andrology, December 19, 2012
195 Evaluation of Testicular Sperm CRISP2 as a Potential Target for Contraception Journal of Andrology, December 19, 2012
196 The High Frequency of Sperm Aneuploidy in Klinefelter Patients and in Nonobstructive Azoospermia Is Due to Meiotic Errors in Euploid Spermatocytes Journal of Andrology, December 19, 2012
197 Association of the IL1RN Gene VNTR Polymorphism with Human Male Infertility PLOS ONE, December 19, 2012
198 Analysis of Relation Between C677T Genotype in MTHFR Gene and Prostatic Cancer in Iranian Males Full Text Acta Medica Iranica, December 17, 2012
199 Distinct Function of Estrogen Receptor {alpha} in Smooth Muscle and Fibroblast Cells in Prostate Development Molecular Endocrinology, December 17, 2012
200 Micro-RNAs, next-generation molecular markers in male infertility field Full Text Translational Andrology and Urology, December 17, 2012
Clinical Pearls in Urology
- Because temozolomide is associated with changes in male fertility, consider referring patients for sperm banking prior to initiating chemotherapy for glioblastoma multiforme (GBM)
- The schedule of radium-223 used in the ALSYMPCA trial is 5 minute infusion every 4 weeks x6 doses. Given in this fashion, it significantly improved median OS, time to SRE and time to PSA progression in men with advanced cancer of the prostate without demonstrable side effects
- In RTOG 94-08 the addition of short course androgen deprivation to radiation therapy for men with intermediate risk cancer of the prostate resulted in a 50% reduction in disease specific mortality at 10-years
Highlights in Urology
Red meat cooked at high temperatures increases risk of advanced cancer of the prostate
Researchers at the University of Southern California have reported a risk between advanced cancer of the prostate and red meats cooked at high temperature, pan-frying, and prepared "well done." The study involved 1140 men with advanced cancer of the prostate, 717 men with localized cancer of the prostate, and 1096 healthy controls from the California Collaborative Prostate Cancer Study. There was an inverse association between baked poultry and advanced prostate cancer.
Read the article summaryRisk factors for delirium post-radical cystectomy
Researchers at the University of Chicago Pritzker School of Medicine have reported that older age and the pre-operative MMSE results are associated with post-radical cystectomy (OR = 1.52) in patients > 65 years of age (n=49). The incidence of post-operative delirium was 29%. Further, patients with post-operative delirium were at increased risk for readmission (OR = 10.7) and re-operation (OR = 9.2).
Read the article summaryPSA screening reduces risk of metastatic cancer of the prostate
As published in European Neurology, men (age range, 55-69 years) who undergo PSA screening are at decreased risk for metastatic cancer of the prostate. The study involved 76,813 men with a median follow-up of 12 y. There were 666 cases with metastatic cancer of the prostate(256 screened [.67%/1000] and 410 non-screened [.86%/1000]). The HR for men who were screened was 0.58.
Read the article summaryMost Popular Urology Articles
Last month's top read Top Articles of 20121 Routine urine cytology has no role in hematuria investigations The Journal of Urology, April 18, 2013
2 A retrospective study of clinical outcomes of alpha-blocker or finasteride monotherapy followed by combination therapy: determination of the period of combination therapy of -alpha blocker and finasteride International Journal of Clinical Practice, April 9, 2013
3 Abiraterone and Novel Antiandrogens: Overcoming Castration Resistance in Prostate Cancer Annual Review of Medicine, April 26, 2013 Review Article
4 Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Crossover Study Gynecologic and Obstetric Investigation, April 12, 2013
5 Pleasure and Pain: The Effect of (Almost) Having an Orgasm on Genital and Nongenital Sensitivity The Journal of Sexual Medicine, April 23, 2013 Review Article
6 Effect of intrinsic sphincter deficiency on midurethral sling outcomes in women with mixed urinary incontinence Female Pelvic Medicine & Reconstructive Surgery, April 26, 2013
7 Screening for Prostate Cancer: A Guidance Statement From the Clinical Guidelines Committee of the American College of Physicians Annals of Internal Medicine, April 10, 2013 Clinical Guideline
8 Independent Cellular Effects of Cold Ischemia and Reperfusion: Experimental Molecular Study Transplantation Proceedings, April 29, 2013 Review Article
9 Anterior urethral stricture review Translational Andrology and Urology, April 4, 2013 Free full text Review Article
10 An open-label, long-term evaluation of the safety, efficacy and tolerability of avanafil in male patients with mild to severe erectile dysfunction International Journal of Clinical Practice, April 9, 2013
11 Smoking status modifies the relation between cyp1a1*2c gene polymorphism and idiopathic male infertility the importance of gene–environment interaction analysis for genetic studies of the disease Reproductive Sciences, April 9, 2013
12 Brg1 Determines Urothelial Cell Fate during Ureter Development Journal of the American Society of Nephrology, March 1, 2013 Review Article
13 Erectile dysfunction in the cardiovascular patient European Heart Journal, April 29, 2013
14 Severity of Urinary Incontinence and Effect on Quality of Life in Women by Incontinence Type Obstetrics and Gynecology, April 26, 2013
15 The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis Journal of Andrology, April 1, 2013
16 Expression of CX3CR1 associates with cellular migration, metastasis, and prognosis in human clear cell renal cell carcinoma Urologic Oncology: Seminars and Original Investigations, April 26, 2013
17 Early and Complete Excision of Vaginally Placed Synthetic Mesh Female Pelvic Medicine & Reconstructive Surgery, April 26, 2013
18 Sperm motility and DNA integrity affected by different g-forces in the preparation of sperm in urine specimens Andrologia, April 5, 2013
19 Location and Characterization of GAPDS in Male Reproduction Urologia Internationalis, February 4, 2013 Review Article
20 Genes associated with prostate cancer are differentially expressed in African American and European American men Cancer Epidemiology, Biomarkers & Prevention, March 26, 2013 Review Article
Indexed Journals in Urology: Urology, Journal of Urology, European Urology, The Prostate more
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