Urology News Articles

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Search today's latest Urology news articles updated daily summarizing the most recent top clinical literature from over 2,000 peer-reviewed journals, including Journal of Urology, European Urology, The Prostate, and more. Read coverage of the kidney, bladder, penis/urethra and prostate. View article summaries by subspecialty and disease state, including pediatric urology, urologic oncology, kidney stone disease, infections and STDs, urologic imaging, ureteral disorders, voiding and incontinence, infertility, laparoscopy and other surgical techniques in Urology.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 An investigation into the relationship between Statins and Cancer using population-based data BJU International, September 23, 2014    Clinical Article

2 Degarelix as an intermittent androgen deprivation therapy for one or more treatment cycles in patients with prostate cancer Full Text European Urology, September 23, 2014    Clinical Article

3 Cabozantinib in chemotherapy-pretreated metastatic castration-resistant prostate cancer: Results of a phase II nonrandomized expansion study Journal of Clinical Oncology, September 23, 2014    Clinical Article

4 Adherence to dietary and lifestyle recommendations and prostate cancer risk in the prostate testing for cancer and treatment (ProtecT) trial Cancer Epidemiology, Biomarkers & Prevention, September 23, 2014    Clinical Article

5 Trans-pacific variation in outcomes for men treated with primary androgen deprivation therapy for prostate cancer BJU International, September 23, 2014    Clinical Article

6 Systemic therapy in men with metastatic castration-resistant prostate cancer: American Society of Clinical Oncology and Cancer Care Ontario Clinical Practice Guideline Journal of Clinical Oncology, September 23, 2014    Clinical Guideline    Clinical Article

7 Function of PCA3 in prostate tissue and clinical research progress on developing a PCA3 score Full Text Chinese Journal of Cancer Research, September 23, 2014    Review Article

8 Retropubic, laparoscopic, and robot-assisted radical prostatectomy: Surgical, oncological, and functional outcomes: A systematic review Urologia Internationalis, September 23, 2014    Evidence Based Medicine    Review Article

9 Trigonal versus extratrigonal botulinum toxin-A: A systematic review and meta-analysis of efficacy and adverse events International Urogynecology Journal, September 23, 2014    Review Article

10 Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis Cancer Research, September 23, 2014    Clinical Article

11 Direct estradiol and diethylstilbestrol actions on early- versus late-stage prostate cancer cells The Prostate, September 23, 2014    Clinical Article

12 18F-FDG PET/CT superscan in prostate cancer Clinical Nuclear Medicine , September 23, 2014

13 miR-146a functions as a tumor suppressor in prostate cancer by targeting Rac1 The Prostate, September 23, 2014    Clinical Article

14 Co-targeting androgen receptor and DNA for imaging and molecular radiotherapy of prostate cancer: In vitro studies The Prostate, September 23, 2014

15 Epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells The Prostate, September 23, 2014    Clinical Article

16 Bladder outlet obstruction and BPH Current Bladder Dysfunction Reports, September 23, 2014    Review Article

17 Prevention of urinary tract infection for patients with neurogenic bladder Current Bladder Dysfunction Reports, September 23, 2014    Clinical Article

18 Detection of a metastatic lesion and tiny yolk sac tumors in two teenage patients by FDG-PET: report of two cases Surgery Today, September 23, 2014

19 Transurethral excision of prolapsed ureterocele International Urogynecology Journal, September 23, 2014    Clinical Article

20 Backstroke? Australian crawl? Sperm vary swim strokes UW Medicine, September 23, 2014

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Highlights in Urology

Chromogranin A staining as a biomarker for prostate adenocarcinoma

As reported in The Prostate, chromogranin A (CgA) staining, an indicator of neuroendocrine differentiation, is associated with decreased biochemical control, clinical failure, increased distant metastases, and decreased cause-specific survival in patients with prostate adenocarcinoma and a GS ≥ 7 (n=285). The median follow-up was 6.5 y. CgA staining was present in 31% of specimens. The 10-y distant metastases rate in specimens with <1% and >1% CgA staining was 8% and 48%, respectively. The 10-y cause-specific survival in specimens with <1% and >1% CgA staining was 95% vs. 76%, respectively.

GALNT4 predicts survival in patients with ccRCC

As reported in the Journal of Urology, N-acetylgalactosaminyltransferase 4 (GALNT4) levels are decreased in tumor specimens from patients with clear cell renal cell carcinoma (ccRCC; n=104) compared to peritumoral specimens. Decreased expression of GALNT4 is associated with poor OS (OR=3.08) and RFS (OR=2.17). Further, GALNT4 is negatively correlated with tumor size, necrosis, and TNM stage.

PCA3 useful for early diagnosis of prostate cancer

Based on a meta-analysis reported in the Chinese Medical Journal, prostate cancer antigen 3 (PCA3) can be used for the early diagnosis of prostate cancer and to avoid unnecessary biopsies, with a sensitivity of 0.82, a specificity of 0.962, a positive likelihood ratio of 2.39, a negative likelihood ratio of 0.51, and a diagnostic odds ratio of 4.89.

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