We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1EAU guidelines on the assessment of non-neurogenic male lower urinary tract symptoms including benign prostatic obstructionEuropean Urology, May 22, 2015  Full Text
2Systematic review and meta-analysis of factors determining change to radical treatment in active surveillance for localized prostate cancerEuropean Urology, May 22, 2015  Full Text  Evidence Based Medicine  Review Article
3Pre-diagnostic obesity and physical inactivity are associated with shorter telomere length in prostate stromal cellsCancer Prevention Research, May 22, 2015  Clinical Article
4Metastasis initiating cells in primary prostate cancer tissues from transurethral resection of the prostate (TURP) predicts castration-resistant progression and survival of prostate cancer patientsThe Prostate, May 22, 2015  Clinical Article
5Magnetic resonance imaging on disease reclassification among active surveillance candidates with low-risk prostate cancer: A diagnostic meta-analysisProstate Cancer & Prostatic Diseases, May 22, 2015  Clinical Article
6Natural history of pathologically benign multi-parametric MRI cancer suspicious regions following MRI-ultrasound fusion-targeted biopsyThe Journal of Urology, May 22, 2015  Clinical Article
7High-throughput transcriptomic analysis nominates proteasomal genes as age-specific biomarkers and therapeutic targets in prostate cancerProstate Cancer & Prostatic Diseases, May 22, 2015  Clinical Article
8Population-based study of long-term functional outcomes after prostate cancer treatmentBJU International, May 22, 2015  Clinical Article
9Tumor expression of adiponectin receptor 2 and lethal prostate cancerCarcinogenesis, May 22, 2015  Clinical Article
10Differential post-prostatectomy cancer-specific survival of occult T3 vs. clinical T3 prostate cancer: Implications for managing patients upstaged on prostate magnetic resonance imagingUrologic Oncology: Seminars and Original Investigations, May 22, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1What drives advanced prostate cancer? New study describes genomic landscapeUniversity of Michigan Health System, May 22, 2015
2International study of advanced prostate cancer genome finds abundance of potential targets for drug therapyDana-Farber Cancer Institute, May 22, 2015
3Scientists unveil prostate cancer's 'Rosetta Stone'Institute of Cancer Research, May 22, 2015
4Biomarkers to improve prostate cancer screeningAmerican Urological Association News, May 21, 2015
5New studies call for improved assessment of prostate cancer screening and treatment selectionAmerican Urological Association News, May 21, 2015
6New studies call for smarter approach to prostate cancer screeningAmerican Urological Association News, May 21, 2015
7Men with asthma less likely to develop lethal prostate cancerJohns Hopkins Medicine, May 21, 2015
8Researchers focus on potential tool for predicting survival, staging prostate cancer in Cancer CellIndiana University School of Medicine News, May 21, 2015
9Atrial fibrillation after surgery increases risk of heart attacks and strokes, Loyola study findsLoyola University Health System, May 21, 2015
10Mayo urologists present findings at 2015 American Urological Association 2015 MeetingMayo Clinic, May 21, 2015

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Water restriction improves nocturia

As reported in the International Journal of Urology, daytime/night-time water restriction significantly improves nocturia in patients with urine production ≥ 30 mL/kg.

3-month PSA is a predictor of BCR-free survival after radical prostatectomy

As reported in the International Journal of Clinical Oncology, the 5-year biochemical recurrence (BCR)-free survival rate is significantly higher in patients with a 3-month PSA level < 0.010 ng/ml compared to patients with a 3-month PSA level between 0.010 and 100 ng/ml (92.6% vs. 57.4%). Amongst 174 men who underwent radical prostatectomy for clinically localized prostate cancer, 18.4% had a BCR and the median time to BCR was 16 months.

Chromogranin A staining as a biomarker for prostate adenocarcinoma

As reported in The Prostate, chromogranin A (CgA) staining, an indicator of neuroendocrine differentiation, is associated with decreased biochemical control, clinical failure, increased distant metastases, and decreased cause-specific survival in patients with prostate adenocarcinoma and a GS ≥ 7 (n=285). The median follow-up was 6.5 y. CgA staining was present in 31% of specimens. The 10-y distant metastases rate in specimens with <1% and >1% CgA staining was 8% and 48%, respectively. The 10-y cause-specific survival in specimens with <1% and >1% CgA staining was 95% vs. 76%, respectively.

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Clinical Pearls

Clinical Pearl from Smartest DocCirculating 25-hydroxyvitamin D is not associated with fatal prostate cancer.

Clinical Pearl from Smartest DocOutcomes of parenteral treatment in infants with bacteremic urinary tract infection are excellent.

Clinical Pearl from Smartest DocInjectable testosterone undecanoate and daily tadalafil aids in erectile dysfunction with testosterone deficiency syndrome.

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