We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1National prostate cancer screening rates after the 2012 US Preventive Services Task Force recommendation discouraging prostate-specific antigen–based screeningJournal of Clinical Oncology, July 06, 2015  Clinical Article
2Added value of multiparametric ultrasonography in magnetic resonance imaging and ultrasonography fusion-guided biopsy of the prostate in patients with suspicion for prostate cancerUrology, July 06, 2015  Clinical Article
3Efficacy and safety of abiraterone acetate in elderly (≥ 75 years) chemotherapy-naïve patients with metastatic castration-resistant prostate cancerThe Journal of Urology, July 06, 2015  Clinical Article
4Does postoperative leukocyturia influence treatment outcomes after photoselective vaporization of the prostate (PVP)?: A prospective short-term serial follow-up studyUrology, July 06, 2015  Clinical Article
5Real-time cancer diagnosis during prostate biopsy: Ex vivo evaluation of full-field optical coherence tomography (FFOCT) imaging on biopsy coresWorld Journal of Urology, July 06, 2015  Clinical Article
6Urinary bladder contractility revisited. correlation of noninvasively and invasively measured contractility parameters in patients eligible for transurethral resection of the prostateUrology, July 06, 2015  Clinical Article
7The genomic evolution of human prostate cancerBritish Journal of Cancer, July 06, 2015  Review Article
8Salvage robot assisted radical prostatectomy: a propensity matched study of perioperative, oncological and functional outcomesEuropean Journal of Surgical Oncology, July 06, 2015  Clinical Article
9Novel technique prevents lymphoceles after transperitoneal robotic-assisted pelvic lymph node dissection: Peritoneal flap interpositionUrology, July 06, 2015  Clinical Article
10Trends of systemic therapy use for renal cell carcinoma in the United StatesUrology, July 06, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1New mechanism for male infertility discoveredKarolinska Institutet, July 06, 2015
2Re-engineered antibiotic shows potential for treatment of drug-resistant bacteriaSt. Jude Children's Research Hospital News, July 06, 2015
3New radiotherapy technique could target prostate cancer while reducing side-effectsInstitute of Cancer Research, July 02, 2015
4Human urine helps prevent bacteria from sticking to bladder cellsAmerican Society for Microbiology News, July 02, 2015
5Penn team identifies gene responsible for some cases of male infertilityUniversity of Pennsylvania News, July 02, 2015
6Long-term survival rates satisfactory for bladder cancer patients treated with robotic surgeryRoswell Park Cancer Institute News, June 30, 2015
7New and innovative approach for successful vaccination against Chlamydia infectionsMedical University of Vienna, June 26, 2015
8Sperm meets egg: Mystery event may play key role in fertilizationUniversity of Virginia Health System News, June 26, 2015
9A person's diet, acidity of urine may affect susceptibility to UTIsWashington University School of Medicine in St. Louis News, June 26, 2015
10Breast cancer gene signature predicts bladder cancer progressionNorris Cotton Cancer Center News, June 26, 2015

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Chromogranin A staining as a biomarker for prostate adenocarcinoma

As reported in The Prostate, chromogranin A (CgA) staining, an indicator of neuroendocrine differentiation, is associated with decreased biochemical control, clinical failure, increased distant metastases, and decreased cause-specific survival in patients with prostate adenocarcinoma and a GS ≥ 7 (n=285). The median follow-up was 6.5 y. CgA staining was present in 31% of specimens. The 10-y distant metastases rate in specimens with <1% and >1% CgA staining was 8% and 48%, respectively. The 10-y cause-specific survival in specimens with <1% and >1% CgA staining was 95% vs. 76%, respectively.

High expression of MUC1 + HER3 is associated with favorable outcome in bladder cancer patients

As reported in BJU International, elevated co-expression of MUC1 + HER3 was associated with improved survival in patients with bladder cancer. MUC1 alone, or elevated MUC1 + non-elevated HER3, had no prognostic value. Moreover, MUC1 was not predictive of survival, tumor stage, or tumor grade.

PCA3 useful for early diagnosis of prostate cancer

Based on a meta-analysis reported in the Chinese Medical Journal, prostate cancer antigen 3 (PCA3) can be used for the early diagnosis of prostate cancer and to avoid unnecessary biopsies, with a sensitivity of 0.82, a specificity of 0.962, a positive likelihood ratio of 2.39, a negative likelihood ratio of 0.51, and a diagnostic odds ratio of 4.89.

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Clinical Pearls

Clinical Pearl from Smartest DocKidney stone formers should be advised to limit the intake of animal proteins, including fish.

Clinical Pearl from Smartest DocProstate cancer arises in the transition zone in 20-25% of cases.

Clinical Pearl from Smartest DocThere is no detectable relationship between bladder cancer mortality and lymph node count.

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