Impact of Biological Gender and Soluble Guanylate Cyclase Stimulation on Renal Recovery After Relief of Unilateral Ureteral Obstruction
The Journal of Urology, 06/15/2012
Wang–Rosenke Y et al. – Female gender is protective for unilateral ureteral obstruction relief. This was linked to higher sensitivity of the soluble guanylate cyclase enzyme and cyclic guanosine monophosphate production in response to BAY 41–8543. In these female and male rats enhancing the signaling of nitric oxide/cyclic guanosine monophosphate with BAY 41–8543 significantly accelerated the restoration of renal architecture after obstruction relief and largely ameliorated the differences in disease severity due to the gender disparity.