Statin use and fatal prostate cancer
Cancer,  Clinical Article

Marcella SW et al. – Statin use was associated with substantial protection against prostate cancer death, adding to the epidemiologic evidence for an inhibitory effect on prostate cancer.

Methods
  • This was a matched case-control study.
  • Cases were residents of New Jersey ages 55 to 79years who died from prostate cancer between 1997 and 2000.
  • The cases were matched individually to population-based controls by 5-year age group and race.
  • Medication data were obtained identically for cases and controls from blinded medical chart review.
  • Conditional logistic regression was used to adjust for confounders.

Results
  • In total, 718 cases were identified, and cooperation was obtained from 77% of their spouses (N=553).
  • After a review of medical records, 387 men were eligible, and 380 were matched to a control.
  • The unadjusted odds ratio was 0.49 (95% confidence interval, 0.34-0.70) and decreased to 0.37 (P<.0001) after adjusting for education, waist size, body mass index, comorbidities, and antihypertensive medication.
  • There was little difference between lipophilic and hydrophilic statins, but more risk reduction was noted for high-potency statins (73%; P<.0001) compared with low-potency statins (31%; P=.32).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Urology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Urology Articles

1 Prostate cancer antigen 3 test for prostate biopsy decision: A systematic review and meta analysis Full Text Chinese Medical Journal, May 22, 2014    Free full text    Evidence Based Medicine    Review Article

2 Pomegranate juice and prostate cancer: Importance of the characterisation of the active principle Phytotherapy Research, June 10, 2014    Clinical Article

3 Prostate cancer and the influence of dietary factors and supplements: A systematic review Full Text Nutrition & Metabolism, June 20, 2014    Free full text    Review Article

4 Prospective evaluation of MRI-guided in-bore prostate biopsy versus systematic transrectal ultrasound (TRUS)-guided prostate biopsy in biopsy-naïve men with elevated prostate-specific antigen (PSA) levels The Journal of Urology, June 13, 2014    Clinical Article

5 Modeling and analysis of Gleason score 8-10 prostate cancers in the REDUCE study Urology, June 12, 2014    Clinical Article

6 Effect of tadalafil once daily on prostate blood flow and perfusion in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia: A randomized, double-blind, multicenter, placebo-controlled trial Urology, June 17, 2014    Clinical Article

7 Evolution of repeat prostate biopsy strategies incorporating transperineal and MRI-TRUS fusion techniques World Journal of Urology, June 16, 2014    Clinical Article

8 Margin involvement at prostatectomy for clinically localized prostate cancer: Does a low-risk group exist? Practical Radiation Oncology, June 6, 2014    Clinical Article

9 Efficacy and safety of fesoterodine 8 mg in subjects with overactive bladder after a suboptimal response to tolterodine ER International Journal of Clinical Practice, June 11, 2014    Clinical Article

10 Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound–guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies Full Text European Urology, June 26, 2014    Free full text    Clinical Article

11 Screening for prostate cancer with the prostate-specific antigen test: A review of current evidence JAMA, March 20, 2014    Evidence Based Medicine    Clinical Article

12 Is there an anti-androgen withdrawal syndrome with enzalutamide? BJU International, June 18, 2014    Clinical Article

13 Processed meat intake is unfavorably and fish intake favorably associated with semen quality indicators among men attending a fertility clinic The Journal of Nutrition, May 30, 2014    Clinical Article

14 Metabolic syndrome-like components and prostate cancer risk: Results from the REDUCE Study BJU International, June 19, 2014    Clinical Article

15 Low detectable PSA after radical prostatectomy: Treat or watch? The Journal of Urology, June 4, 2014    Clinical Article

16 Health care costs for prostate cancer patients receiving androgen deprivation therapy: Treatment and adverse events Full Text Current Oncology, June 24, 2014    Free full text    Clinical Article

17 Long-term treatment patterns of testosterone replacement medications The Journal of Sexual Medicine, June 12, 2014    Clinical Article

18 Comparison of image-guided targeted biopsies versus systematic randomized biopsies in the detection of prostate cancer: A systematic literature review of well-designed studies World Journal of Urology, June 16, 2014    Review Article

19 Chemoprevention of prostate cancer Annual Review of Medicine, March 13, 2014    Review Article    Clinical Article

20 Antibiotics are not beneficial in the management of category III prostatitis: A meta-analysis Full Text Urology Journal, June 10, 2014    Free full text    Evidence Based Medicine    Review Article

Indexed Journals in Urology: Urology, Journal of Urology, European Urology, The Prostatemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close