Statin use and fatal prostate cancer
Cancer,  Clinical Article

Marcella SW et al. – Statin use was associated with substantial protection against prostate cancer death, adding to the epidemiologic evidence for an inhibitory effect on prostate cancer.

Methods
  • This was a matched case-control study.
  • Cases were residents of New Jersey ages 55 to 79years who died from prostate cancer between 1997 and 2000.
  • The cases were matched individually to population-based controls by 5-year age group and race.
  • Medication data were obtained identically for cases and controls from blinded medical chart review.
  • Conditional logistic regression was used to adjust for confounders.

Results
  • In total, 718 cases were identified, and cooperation was obtained from 77% of their spouses (N=553).
  • After a review of medical records, 387 men were eligible, and 380 were matched to a control.
  • The unadjusted odds ratio was 0.49 (95% confidence interval, 0.34-0.70) and decreased to 0.37 (P<.0001) after adjusting for education, waist size, body mass index, comorbidities, and antihypertensive medication.
  • There was little difference between lipophilic and hydrophilic statins, but more risk reduction was noted for high-potency statins (73%; P<.0001) compared with low-potency statins (31%; P=.32).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Urology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Urology Articles

1 Who dies from prostate cancer? Prostate Cancer & Prostatic Diseases, October 17, 2014    Clinical Article

2 The use of metformin in patients with prostate cancer and the risk of death Cancer Epidemiology, Biomarkers & Prevention, September 22, 2014    Clinical Article

3 Diethylstilboestrol (1 mg) in the management of castration-resistant prostate cancer Urologia Internationalis, October 21, 2014    Clinical Article

4 Daily aspirin use and prostate cancer–specific mortality in a large cohort of men with nonmetastatic prostate cancer Journal of Clinical Oncology, October 24, 2014    Clinical Article

5 The impact of PSA and digital rectal examination on the risk of prostate cancer specific mortality in men with a PSA level <2.5 ng/ml Cancer Epidemiology, September 26, 2014    Clinical Article

6 Prevention and early detection of prostate cancer The Lancet Oncology, October 7, 2014    Review Article

7 Highly-trained dogs' olfactory system detects prostate cancer in urine samples The Journal of Urology, October 20, 2014    Clinical Article

8 Concordance between biopsy and radical prostatectomy specimen gleason score in internal and external pathology facilities Anticancer Research, October 22, 2014    Clinical Article

9 Salvage focal prostate cryoablation for locally recurrent prostate cancer after radiotherapy: Initial results from the cryo on-line data registry The Prostate, October 9, 2014    Clinical Article

10 Particle radiotherapy for prostate cancer International Journal of Urology, October 23, 2014    Review Article

11 Prostate cancer incidence, clinical stage and survival in relation to obesity: A prospective cohort study in Denmark International Journal of Cancer, October 2, 2014    Clinical Article

12 Biologic differences between peripheral and transition zone prostate cancer The Prostate, October 28, 2014    Clinical Article

13 Dutasteride and enzalutamide synergistically suppress prostate tumor cell proliferation The Journal of Urology, October 30, 2014    Clinical Article

14 Smoking and risk of low- and high-grade prostate cancer: Results from the REDUCE study Clinical Cancer Research, September 19, 2014    Clinical Article

15 Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA) The Prostate, October 1, 2014    Clinical Article

16 Accuracy of the prostate health index versus the urinary prostate cancer antigen 3 score to predict overall and significant prostate cancer at initial biopsy The Prostate, October 29, 2014    Clinical Article

17 Hormone and radiotherapy versus hormone or radiotherapy alone for non-metastatic prostate cancer: A systematic review with meta-analyses Clinical Oncology, August 8, 2014    Evidence Based Medicine    Review Article

18 Gleason stratifications prognostic for survival in men receiving definitive external beam radiation therapy for localized prostate cancer Urologic Oncology: Seminars and Original Investigations, October 16, 2014    Clinical Article

19 Stereotactic body radiation therapy for prostate cancer: Review of experience of a multicenter phase I/II dose escalation study Frontiers in Oncology, October 13, 2014    Review Article    Clinical Article

20 Silodosin for the treatment of clinical benign prostatic hyperplasia: Safety, efficacy, and patient acceptability Full Text Research and Reports in Urology, October 6, 2014    Free full text    Review Article

Indexed Journals in Urology: Urology, Journal of Urology, European Urology, The Prostatemore