Regulation of thrombomodulin expression in prostate cancer cells

Cancer Letters, 05/11/2012

The study establishes that in prostate cancer cell lines relative to prostate epithelial cells (PrEC) the thrombomodulin (TM) is down–regulated and that the TM promoter is hypermethylated, which seems to be responsible for the down–regulation and failed regulation of TM expression in DU–145 cells.

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