A Phase 2 Pharmacodynamic Study of Pre-operative Figitumumab in Patients with Localized Prostate Cancer
Clinical Cancer Research, 05/03/2012Chi KN et al.
Figitumumab is biologically active in prostate cancer. PSA declines in treatment naive patients were observed, potentially mediated by insulin–like growth factor 1 receptor (IGF–IR) effects on androgen receptor expression. These results support the clinical relevance of IGF–IR signalling in prostate cancer and justify further clinical trials.
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