Detrusor underactivity in men following radical retropubic prostatectomy - prevalence, importance and evaluation
Current Bladder Dysfunction Reports, May 14, 2013
Elliott CS et al. - This paper will review: a) the difficulty in defining detrusor underactivity in men after radical prostatectomy; b) the incidence of urodynamic detrusor underactivity after radical prostatectomy; and c) the potential importance of this finding in men seeking treatment for post radical prostatectomy incontinence.
Phosphorylation Status of Fas-associated Death Domain Protein Is Associated With Biochemical Recurrence After Radical Prostatectomy
Urology, February 12, 2013
Ikeda T et al. – The study aims to assess whether the phosphorylated Fas–associated death domain protein (FADD) at 194 serine (p–FADD) is valuable as a marker of biochemical recurrence in hormone–naive patients who had undergone radical prostatectomy. A low expression of p–FADD could be a predictor of biochemical recurrence in hormone–naive patients who have undergone radical prostatectomy. Methods The authors used radical prostatectomy specimens from 106 patients. None of the patients ...
18F-fluoroethylcholine PET/CT identifies lymph node metastasis in patients with prostate-specific antigen failure after radical prostatectomy but underestimates its extent
European Urology, May 3, 2013
Tilki D et al. - This study aimed to evaluate the accuracy of combined 18F–fluoroethylcholine (FEC) positron emission tomography (PET)/computed tomography (CT) in the detection of LNMs in prostate cancer (PCa) patients with rising prostate-specific antigen (PSA) level after radical prostatectomy. A positive 18F-FEC PET/CT result correctly predicted the presence of LNM in the majority of PCa patients with biochemical failure after radical prostatectomy but did not allow for ...
A phase 3, placebo controlled study of the safety and efficacy of avanafil for the treatment of erectile dysfunction after nerve sparing radical prostatectomy
The Journal of Urology, May 16, 2013
Mulhall JP et al. - Authors evaluated the safety and efficacy of 100 and 200 mg avanafil for the treatment of adult males with erectile dysfunction after bilateral nerve sparing radical prostatectomy. Avanafil in 100 and 200 mg doses was effective and well tolerated in improving erectile function after prostatectomy. Results suggest a rapid onset of action and sustained duration of effect, with all 3 primary end points being achieved at both dose levels. Methods This was a ...
Contemporary grading for prostate cancer: implications for patient care
European Urology, May 8, 2013
Brimo F et al. - This study aimed to provide an overview of the implementation and the impact of the Gleason system as a predictive and prognostic tool in all available treatment modalities, and to compare the original and modified Gleason systems in major pathologic and clinical outcome data sets. The Gleason score is one of the most critical predictive factors of prostate cancer regardless of the therapy used. Modernization of the Gleason grading system has resulted in a more ...
Results of preoperative electrical stimulation of pelvic floor muscles in the continence status following radical retropubic prostatectomy
International Braz J Urol, May 9, 2013
Laurienzo CE et al. - This study aimed to evaluate preoperative rectal electrical stimulation in the recovery of urinary continence in patients who undergo radical retropubic prostatectomy. Preoperative rectal electrical stimulation has no impact on continence status in patients who undergo radical retropubic prostatectomy. There is no difference in the three above mentioned groups with regard to urinary leakage and quality of life. Methods Patients were divided into 3 ...
Plan of the day selection for online image-guided adaptive post-prostatectomy radiotherapy
Radiotherapy & Oncology, May 10, 2013
Gill S et al. - This study aimed to compare the cone-beam CT (CBCT) soft tissue localization disparity between radiation oncologists (RO) and radiation therapy technologists (RTT) in a novel online protocol of image-guided adaptive radiotherapy to the postoperative prostate bed. The difference between RTT and RO selection of adaptive volumes is small and can be accounted for in a clinically acceptable CTV to PTV margin. Adaptive post-prostatectomy radiotherapy is ...
VEGFR1 and NRP1 Endothelial Expressions Predict Distant Relapse after Radical Prostatectomy in Clinically Localized Prostate Cancer
Anticancer Research, May 10, 2013
Talagas M et al. - Prostate cancer can usually be treated at a clinically localized stage by radical prostatectomy. Unfortunately, within 10 years following surgery, 30% of patients experience local or distant relapse. Few data exist on the association of markers of angiogenesis and distant relapse after radical prostatectomy. The evaluation by immunohistochemistry of endothelial expression of neuropilin 1 and VEGFR1 could be an additional tool in the assessment of tumor aggressiveness ...
Magnetic resonance imaging to detect vesico-symphyseal fistula following robotic prostatectomy
International Braz J Urol, May 20, 2013
Hutchinson RC et al. - Pubic complications following radical prostatectomy are rare. Osteitis pubis typically presents with symptoms related to irritation of the pubic rami including pain with ambulation and adduction of the leg. A 60-year-old male with prostatic adenocarcinoma underwent uneventful robotic assisted laparoscopic prostatectomy. The patient noted the onset of severe pubic pain exacerbated by ambulation approximately one month post-surgery. An ...
Gleason Score 7 Adenocarcinoma of the Prostate With Lymph Node Metastases: Analysis of 184 Radical Prostatectomy Specimens
Archives of Pathology & Laboratory Medicine, May 1, 2013
Kryvenko ON et al. - The aim of this study is to determine clinicopathologic features associated with GS 7 PC with LN+ compared with a control group without lymph node metastases (LN-). Gleason score 7 PC with LN+ has features highlighting a more-aggressive phenotype. These features can be assessed as prognostic markers in GS 7 disease on biopsy or at radical prostatectomies (all variables), even in men without LN dissection or LN disease.